B(C6F5)3-catalyzed Markovnikov addition of indoles to aryl alkynes: an approach toward bis(indolyl)alkanes

被引：34

作者：

Ling, Fei ^{[1
]}

Xiao, Lian ^{[1
]}

Fang, Lu ^{[1
]}

Feng, Cong ^{[1
]}

Xie, Zhen ^{[1
]}

Lv, Yaping ^{[1
]}

Zhong, Weihui ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Minist Educ, Coll Pharmaceut Sci, Key Lab Green Pharmaceut Technol & Related Equipm, Hangzhou 310014, Zhejiang, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2018年 / 16卷 / 47期

基金：

中国国家自然科学基金;

关键词：

FRUSTRATED LEWIS PAIR; H BOND; CARBONYL-COMPOUNDS; TERMINAL ALKYNES; BIS(INDOLYL)METHANE; HYDROAMINATION; HYDROGENATIONS; HETEROARENES; ACTIVATION; EFFICIENT;

D O I：

10.1039/c8ob02805b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first example of the metal- and solvent-free B(C6F5)(3)-catalyzed Markovnikov addition of indoles to aryl alkynes was disclosed. Both N-H and N-protected indoles were tolerated, leading to a wide spectrum of versatile bis(indolyl)alkanes in moderate to good yields with high regioselectivities.

引用

页码：9274 / 9278

页数：5

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