An aerobic copper-mediated domino process for the synthesis of 3-(trifluoromethylseleno)indoles

被引：8

作者：

Wang, Hui ^{[1
,2
]}

Yao, Yunfei ^{[1
,2
]}

You, Yi ^{[1
,2
]}

Huang, Yangjie ^{[3
]}

Weng, Zhiqiang ^{[1
,2
,3
]}

机构：

[1] Fuzhou Univ, Coll Chem, Key Lab Mol Synth & Funct Discovery, Fuzhou 350108, Peoples R China

[2] Fuzhou Univ, Coll Chem, Fujian Prov Key Lab Electrochem Energy Storage Ma, Fuzhou 350108, Peoples R China

[3] Minjiang Univ, Ocean Coll, Fujian Engn Res Ctr New Chinese Lacquer Mat, Fuzhou 350108, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2022年 / 20卷 / 10期

基金：

中国国家自然科学基金;

关键词：

FREE DIRECT TRIFLUOROMETHYLTHIOLATION; ELECTROPHILIC TRIFLUOROMETHYLTHIOLATION; OXIDATIVE TRIFLUOROMETHYLSELENOLATION; INDOLES; 2-(TRIFLUOROMETHYL)INDOLES; FUNCTIONALIZATION; DERIVATIVES; CHLORIDE; REAGENT;

D O I：

10.1039/d2ob00063f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An aerobic copper-mediated domino reaction for the synthesis of 3-(trifluoromethylseleno)indoles by trifluoromethylselenolation of N-Ts 2-alkynylaniline with [(bpy)CuSeCF3](2) is reported. This reaction proceeds through sequential oxidation, alkyne coordination, and deprotonation followed by reductive elimination. This mild and robust method is highly functional group tolerant and provides straightforward access to 3-(trifluoromethylseleno)indoles in moderate to good yields.

引用

页码：2115 / 2120

页数：6

共 49 条

[1] Development of the pan-DAC inhibitor panobinostat (LBH589): Successes and challenges [J].