Mechanistic diversity in MHC class I antigen recognition

被引：14

作者：

Barbosa, Camila R. R. ^{[1
,2
,3
]}

Barton, Justin ^{[4
,5
]}

Shepherd, Adrian J. ^{[4
,5
]}

Mishto, Michele ^{[1
,2
,3
]}

机构：

[1] Kings Coll London, Ctr Inflammat Biol & Canc Immunol CIBCI, London SE1 1UL, England

[2] Kings Coll London, Peter Gorer Dept Immunobiol, London SE1 1UL, England

[3] Francis Crick Inst, London NW1 1AT, England

[4] Birkbeck Univ London, Dept Biol Sci, London WC1E 7HX, England

[5] Birkbeck Univ London, Inst Struct & Mol Biol, London WC1E 7HX, England

来源：

BIOCHEMICAL JOURNAL | 2021年 / 478卷 / 24期

关键词：

ACUTE MYELOID-LEUKEMIA; CD8(+) T-CELLS; CROSS-REACTIVITY; PROTEASOME SUBTYPES; PEPTIDES; EPITOPE; SPECIFICITY; GENERATION; PROTEIN; IMMUNOPROTEASOMES;

D O I：

10.1042/BCJ20200910

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Throughout its evolution, the human immune system has developed a plethora of strategies to diversify the antigenic peptide sequences that can be targeted by the CD8(+) T cell response against pathogens and aberrations of self. Here we provide a general overview of the mechanisms that lead to the diversity of antigens presented by MHC class I complexes and their recognition by CD8(+) T cells, together with a more detailed analysis of recent progress in two important areas that are highly controversial: the prevalence and immunological relevance of unconventional antigen peptides; and cross-recognition of antigenic peptides by the T cell receptors of CD8(+) T cells.

引用

收藏

页码：4187 / 4202

页数：16

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