Initial introduction and spread of the SARS-CoV-2 AY.4.2.1 Delta variant in Bulgaria, a genomic insight

被引：2

作者：

Alexiev, Ivailo ^{[1
]}

Giovanetti, Marta ^{[2
,3
]}

Cella, Eleonora ^{[4
]}

Ivanov, Ivan ^{[1
]}

Stoikov, Ivan ^{[1
]}

Donchev, Deyan ^{[1
]}

Grigorova, Lubomira ^{[1
]}

Gancheva, Anna ^{[1
]}

Dimitrova, Reneta ^{[1
]}

Korsun, Nelly ^{[1
]}

Trifonova, Ivelina ^{[1
]}

Philipova, Ivva ^{[1
]}

Dobrinov, Veselin ^{[1
]}

Grigorova, Iliana ^{[1
]}

Kantardjiev, Todor ^{[1
]}

Christova, Iva ^{[1
]}

Ciccozzi, Massimo ^{[5
]}

机构：

[1] Natl Ctr Infect & Parasit Dis, 44a Gen N Stoletov Blvd, Sofia 1233, Bulgaria

[2] Fundacao Oswaldo Cruz, Lab Flavivirus, Inst Oswaldo Cruz, Rio De Janeiro, Brazil

[3] Univ Campus Biomed Roma, Dept Sci & Technol Humans & Environm, Rome, Italy

[4] Univ Cent Florida, Burnett Sch Biomed Sci, Orlando, FL 32816 USA

[5] Univ Campus Biomed Rome, Unit Med Stat & Mol Epidemiol, Rome, Italy

来源：

JOURNAL OF MEDICAL VIROLOGY | 2022年 / 94卷 / 12期

关键词：

epidemiology; mutation; mutation rate; SARS coronavirus;

D O I：

10.1002/jmv.28033

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The evolution of the emerging SARS-CoV-2 variants carrying mutations in the spike protein raises concerns about the possibility of accelerated transmission in the ever-evolving COVID-19 pandemic worldwide. AY.4.2, a sublineage of the Delta variant, was considered a variant under investigation (VUI) and also gained the nickname "Delta Plus," due to its extra mutations, Y145H and A222V. In this study, using genomic epidemiology, we provide the first insights into the introduction of AY.4.2 in Bulgaria and the AY.4.2.1 sublineage that found larger dissemination only in Bulgaria and the United Kingdom.

引用

页码：6060 / 6064

页数：5

共 23 条

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