Initial introduction and spread of the SARS-CoV-2 AY.4.2.1 Delta variant in Bulgaria, a genomic insight

被引：2

作者：

Alexiev, Ivailo ^{[1
]}

Giovanetti, Marta ^{[2
,3
]}

Cella, Eleonora ^{[4
]}

Ivanov, Ivan ^{[1
]}

Stoikov, Ivan ^{[1
]}

Donchev, Deyan ^{[1
]}

Grigorova, Lubomira ^{[1
]}

Gancheva, Anna ^{[1
]}

Dimitrova, Reneta ^{[1
]}

Korsun, Nelly ^{[1
]}

Trifonova, Ivelina ^{[1
]}

Philipova, Ivva ^{[1
]}

Dobrinov, Veselin ^{[1
]}

Grigorova, Iliana ^{[1
]}

Kantardjiev, Todor ^{[1
]}

Christova, Iva ^{[1
]}

Ciccozzi, Massimo ^{[5
]}

机构：

[1] Natl Ctr Infect & Parasit Dis, 44a Gen N Stoletov Blvd, Sofia 1233, Bulgaria

[2] Fundacao Oswaldo Cruz, Lab Flavivirus, Inst Oswaldo Cruz, Rio De Janeiro, Brazil

[3] Univ Campus Biomed Roma, Dept Sci & Technol Humans & Environm, Rome, Italy

[4] Univ Cent Florida, Burnett Sch Biomed Sci, Orlando, FL 32816 USA

[5] Univ Campus Biomed Rome, Unit Med Stat & Mol Epidemiol, Rome, Italy

来源：

JOURNAL OF MEDICAL VIROLOGY | 2022年 / 94卷 / 12期

关键词：

epidemiology; mutation; mutation rate; SARS coronavirus;

D O I：

10.1002/jmv.28033

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The evolution of the emerging SARS-CoV-2 variants carrying mutations in the spike protein raises concerns about the possibility of accelerated transmission in the ever-evolving COVID-19 pandemic worldwide. AY.4.2, a sublineage of the Delta variant, was considered a variant under investigation (VUI) and also gained the nickname "Delta Plus," due to its extra mutations, Y145H and A222V. In this study, using genomic epidemiology, we provide the first insights into the introduction of AY.4.2 in Bulgaria and the AY.4.2.1 sublineage that found larger dissemination only in Bulgaria and the United Kingdom.

引用

页码：6060 / 6064

页数：5

共 23 条

[1] Aksamentov I, 2021, J OPEN SOURCE SOFTW, P3773, DOI [DOI 10.21105/JOSS.03773, 10.21105/joss.03773]
[2] Postvaccination SARS-CoV-2 Alpha (B.1.1.7) lineage infection among healthcare workers on the background of IgG antibodies
Alexiev, Ivailo
Ivanov, Ivan
Philipova, Ivva
Korsun, Nelly
Stoikov, Ivan
Dimitrova, Reneta
Grigorova, Lubomira
Gancheva, Anna
Trifonova, Ivelina
Dobrinov, Veselin
Grigorova, Iliana
Savov, Alexey
Asenova, Boryana
Ciccozzi, Massimo
Kantardjiev, Todor
[J]. JOURNAL OF MEDICAL VIROLOGY, 2022, 94 (03) : 836 - 839
[3] No evidence for increased cell entry or antibody evasion by Delta sublineage AY.4.2
Arora, Prerna
Kempf, Amy
Nehlmeier, Inga
Graichen, Luise
Winkler, Martin S.
Lier, Martin
Schulz, Sebastian
Jaeck, Hans-Martin
Poehlmann, Stefan
Hoffmann, Markus
[J]. CELLULAR & MOLECULAR IMMUNOLOGY, 2022, 19 (03) : 449 - 452
[4] B.1.617.2 enters and fuses lung cells with increased efficiency and evades antibodies induced by infection and vaccination
Arora, Prerna
Sidarovich, Anzhalika
Krueger, Nadine
Kempf, Amy
Nehlmeier, Inga
Graichen, Luise
Moldenhauer, Anna-Sophie
Winkler, Martin S.
Schulz, Sebastian
Jaeck, Hans-Martin
Stankov, Metodi, V
Behrens, Georg M. N.
Poehlmann, Stefan
Hoffmann, Markus
[J]. CELL REPORTS, 2021, 37 (02):
[5] Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant
Bernal, Jamie Lopez
Andrews, Nick
Gower, Charlotte
Gallagher, Eileen
Simmons, Ruth
Thelwall, Simon
Stowe, Julia
Tessier, Elise
Groves, Natalie
Dabrera, Gavin
Myers, Richard
Campbell, Colin N. J.
Amirthalingam, Gayatri
Edmunds, Matt
Zambon, Maria
Brown, Kevin E.
Hopkins, Susan
Chand, Meera
Ramsay, Mary
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (07) : 585 - 594
[6] DNA Pipelines R&D, 2022, COVID 19 ARTIC V3 IL, DOI 10.17504/protocols.io.bky5kxy6
[7] European Centre for Disease Prevention and Control, 2022, SARS COV 2 VAR 25 MA
[8] Gangavarapu K., 2022, OUTBREAK
[9] A rapid, cost-effective tailed amplicon method for sequencing SARS-CoV-2
Gohl, Daryl M.
Garbe, John
Grady, Patrick
Daniel, Jerry
Watson, Ray H. B.
Auch, Benjamin
Nelson, Andrew
Yohe, Sophia
Beckman, Kenneth B.
[J]. BMC GENOMICS, 2020, 21 (01)
[10] Kupferschmidt K., 2021, SCIENCE

← 1 2 3 →