Synthesis and antimicrobial activity of some new pyridazine derivatives

被引：0

作者：

Caprosu, MD ^{[1
]}

Butnariu, RM ^{[1
]}

Mangalagiu, II ^{[1
]}

机构：

[1] Alexandru Ioan Cuza Univ, Iasi 700506 6, Romania

来源：

HETEROCYCLES | 2005年 / 65卷 / 08期

关键词：

pyridazine; antimicrobial; ylide; cycloaddition; microwave;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Five new pyridazine derivatives (1 salt and 4 pyrrolopyridazine cycloadducts) were prepared and tested in vitro as antimicrobial compounds. Some of them have proved to have a remarkable activity against different micro organisms (germs and fungi). The influence of microwave irradiation concerning cycloaddition reactions of pyridazinium ylides was studied. Stereo- and regiochemistry involved in these reactions are also discussed.

引用

收藏

页码：1871 / 1879

页数：9

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