Synthesis and antimicrobial activity of some new pyridazine derivatives

被引：0
作者：
Caprosu, MD [1 ]
Butnariu, RM [1 ]
Mangalagiu, II [1 ]
机构：
[1] Alexandru Ioan Cuza Univ, Iasi 700506 6, Romania
来源：
HETEROCYCLES | 2005年 / 65卷 / 08期
关键词：
pyridazine; antimicrobial; ylide; cycloaddition; microwave;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Five new pyridazine derivatives (1 salt and 4 pyrrolopyridazine cycloadducts) were prepared and tested in vitro as antimicrobial compounds. Some of them have proved to have a remarkable activity against different micro organisms (germs and fungi). The influence of microwave irradiation concerning cycloaddition reactions of pyridazinium ylides was studied. Stereo- and regiochemistry involved in these reactions are also discussed.
引用
收藏
页码：1871 / 1879
页数：9
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