Synthesis and antimicrobial activity of some new pyridazine derivatives

被引：0
作者：
Caprosu, MD [1 ]
Butnariu, RM [1 ]
Mangalagiu, II [1 ]
机构：
[1] Alexandru Ioan Cuza Univ, Iasi 700506 6, Romania
来源：
HETEROCYCLES | 2005年 / 65卷 / 08期
关键词：
pyridazine; antimicrobial; ylide; cycloaddition; microwave;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Five new pyridazine derivatives (1 salt and 4 pyrrolopyridazine cycloadducts) were prepared and tested in vitro as antimicrobial compounds. Some of them have proved to have a remarkable activity against different micro organisms (germs and fungi). The influence of microwave irradiation concerning cycloaddition reactions of pyridazinium ylides was studied. Stereo- and regiochemistry involved in these reactions are also discussed.
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收藏
页码：1871 / 1879
页数：9
相关论文
共 15 条
[1]   1,3-dipolar cycloaddition reactions of 4-halophenylphthalazinium ylides to activated alkenes and alkynes [J].
Caprosu, MC ;
Zbancioc, GN ;
Moldoveanu, CC ;
Mangalagiu, II .
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 2004, 69 (02) :426-434
[2]  
Dima S, 2000, REV ROUM CHIM, V45, P555
[3]   Synthesis and antinociceptive activity of 6-substituted-3-pyridazinone derivatives [J].
Gokçe, M ;
Dogruer, D ;
Sahin, MF .
FARMACO, 2001, 56 (03) :233-237
[4]  
KLAMANN D, 1991, ORG STICKSTOFF VER 1, P1
[5]  
Lloung M, 2004, HETEROCYCLES, V63, P297
[6]   4-methylpyrimidinium ylides. Part 7: 3+2 Dipolar cycloadditions to non-symmetrical substituted alkenes and alkynes [J].
Mangalagiu, II ;
Mangalagiu, GC ;
Deleanu, C ;
Drochioiu, G ;
Petrovanu, MG .
TETRAHEDRON, 2003, 59 (01) :111-114
[7]  
MOLDOVEANU C, 2003, AN STIINT U AL I CUZ, V11, P367
[8]  
PADWA A, 1984, 1 3 DIPOLAR CYCLOADD, V2, P277
[9]  
Rodríguez H, 2001, HETEROCYCLES, V55, P291
[10]   Synthesis and cytotoxic activity of N,N-bis-{3-[N-(4-chlorobenzo[g]-phthalazin-1-yl)]aminopropyl}-N-methylamine:: A new potential DNA bisintercalator [J].
Rodríguez-Ciria, M ;
Sanz, AM ;
Yunta, MJR ;
Gomez-Contreras, F ;
Navarro, P ;
Fernandez, I ;
Pardo, M ;
Cano, C .
BIOORGANIC & MEDICINAL CHEMISTRY, 2003, 11 (10) :2143-2148
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