Poly(ε-caprolactone) grafted dextran biodegradable electrospun matrix:: A novel scaffold for tissue engineering

被引：33

作者：

Bajgai, Madhab Prasad ^{[2
]}

Aryal, Santosh ^{[3
]}

Bhattarai, Shanta Raj ^{[2
]}

Bahadur, K. C. Remant ^{[4
]}

Kim, Kawn-Woo ^{[2
]}

Kim, Hak Yong ^{[1
]}

机构：

[1] Chonbuk Natl Univ, Dept Text Engn, Chonju 561756, South Korea

[2] Chonbuk Natl Uni, Dept Bionanosyst Engn, Jeonju 561756, South Korea

[3] Chonbuk Natl Uni, Ctr Healthcare Technol Dev, Jeonju 561756, South Korea

[4] Kyungpook Natl Univ, Dept Adv Organ Mat Sci & Engn, Taegu 702701, South Korea

来源：

JOURNAL OF APPLIED POLYMER SCIENCE | 2008年 / 108卷 / 03期

关键词：

biomaterials; biodegradable; matrix; polyester; polysaccharides;

D O I：

10.1002/app.27825

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The main objective of the present work was to fabricate poly (epsilon-caprolactone) grafted dextran (PGD) electrospun matrix (matrix) and to investigate the scaffold potential in tissue engineering application. In this work, at first we synthesized PGD polymer via ring opening polymerization (ROP), and with predetermined electrospinning conditions, nanofibrous matrix with high molecular weight PGD (PGD-50, M-w = 45,500) has been successfully fabricated for the first time. Mouse osteoblast like cells, MC3T3 was used to test biocompatibility, assays of cell adhesion, survival, and effects on cell morphology of the matrix. The data demonstrate that PGD-50 matrix represent a suitable substrate for supporting cell proliferation, process outgrowth and migration and as such would be a good material for artificial extra cellular matrix. (c) 2008 Wiley Periodicals, Inc.

引用

页码：1447 / 1454

页数：8

共 41 条

[1]

ARYAL S, IN PRESS J BIOMED A

[2] Stabilization of gold nanoparticles by thiol functionalized poly(ε-Caprolactone) for the labeling of PCL biocarrier [J].

Aryal, Santosh ;

Bahadur, K. C. Remant ;

Bhattarai, Narayan ;

Lee, Byoung Min ;

Kim, Hak Yong .

MATERIALS CHEMISTRY AND PHYSICS, 2006, 98 (2-3) :463-469

[3] Biodegradable electrospun mat: Novel block copolymer of poly (p-dioxanone-co-L-lactide)-block-poly (ethylene glycol) [J].

Bhattarai, N ;

Cha, DI ;

Bhattarai, SR ;

Khil, MS ;

Kim, HY .

JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS, 2003, 41 (16) :1955-1964

[4] Electrospun chitosan-based nanofibers and their cellular compatibility [J].

Bhattarai, N ;

Edmondson, D ;

Veiseh, O ;

Matsen, FA ;

Zhang, MQ .

BIOMATERIALS, 2005, 26 (31) :6176-6184

[5] Alginate-based nanofibrous scaffolds: Structural, mechanical, and biological properties [J].

Bhattarai, Narayan ;

Li, Zhensheng ;

Edmondson, Dennis ;

Zhang, Miqin .

ADVANCED MATERIALS, 2006, 18 (11) :1463-+

[6] Hydrophilic nanofibrous structure of polylactide; fabrication and cell affinity [J].

Bhattarai, Shanta Raj ;

Bhattarai, Narayan ;

Viswanathamurthi, Periasamy ;

Yi, Ho Keun ;

Hwang, Pyoung Han ;

Kim, Hak Yong .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2006, 78A (02) :247-257

[7] Novel biodegradable electrospun membrane: scaffold for tissue engineering [J].

Bhattarai, SR ;

Bhattarai, N ;

Yi, HK ;

Hwang, PH ;

Cha, DI ;

Kim, HY .

BIOMATERIALS, 2004, 25 (13) :2595-2602

[8]

BHATTARAI SR, IN PRESS J BIOMED A

[9] Synthesis and characterization of biodegradable polylactide-grafted dextran and its application as compatilizer [J].

Cai, Q ;

Wan, YQ ;

Bei, JZ ;

Wang, SG .

BIOMATERIALS, 2003, 24 (20) :3555-3562

[10] Galactose-carrying polymers as extracellular matrices for liver tissue engineering [J].

Cho, CS ;

Seo, SJ ;

Park, IK ;

Kim, SH ;

Kim, TH ;

Hoshiba, T ;

Harada, I ;

Akaike, T .

BIOMATERIALS, 2006, 27 (04) :576-585

← 1 2 3 4 5 →