Concise Review: Adipose-Derived Stromal Vascular Fraction Cells and Stem Cells: Let's Not Get Lost in Translation

被引：190

作者：

Gimble, Jeffrey M. ^{[1
]}

Bunnell, Bruce A. ^{[2
]}

Chiu, Ernest S. ^{[3
]}

Guilak, Farshid ^{[4
]}

机构：

[1] Louisiana State Univ Syst, Stem Cell Biol Lab, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA

[2] Tulane Univ, Med Ctr, Ctr Stem Cell Res & Regenerat Med, New Orleans, LA USA

[3] Tulane Univ, Med Ctr, Dept Surg, Div Plast & Reconstruct Surg, New Orleans, LA USA

[4] Duke Univ, Med Ctr, Dept Orthopaed Surg, Orthopaed Res Lab, Durham, NC USA

来源：

STEM CELLS | 2011年 / 29卷 / 05期

关键词：

Adipose; Adipogenesis; Adult stem cells; Cellular therapy; Stem cell transplantation; Stromal cells; Clinical translation; Current Good Manufacturing Practices; COMPLEX PERIANAL FISTULA; SERUM-FREE; REGENERATIVE THERAPY; IFATS COLLECTION; IN-VITRO; TISSUE; CANCER; AGE; CRYOPRESERVATION; PROTEIN;

D O I：

10.1002/stem.629

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Subcutaneous fat has emerged as an alternative tissue source for stromal/stem cells in regenerative medicine. Over the past decade, international research efforts have established a wealth of basic science and preclinical evidence regarding the differentiation potential and regenerative properties of both freshly processed, heterogeneous stromal vascular fraction cells and culture expanded, relatively homogeneous adipose-derived stromal/stem cells. The stage has been set for clinicians to translate adipose-derived cells from the bench to the bedside; however, this process will involve "development" steps that fall outside of traditional "hypothesis-driven, mechanism-based" paradigm. This concise review examines the next stages of the development process for therapeutic applications of adipose-derived cells and highlights the current state of the art regarding clinical trials. It is recommended that the experiments addressing these issues be reported comprehensively in the peer-review literature. This transparency will accelerate the standardization and reproducibility of adipose-derived cell therapies with respect to their efficacy and safety. STEM CELLS 2011; 29: 749-754

引用

页码：749 / 754

页数：6

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