Heart failure in diabetes

被引：165

作者：

Jankauskas, Stanislovas S. ^{[1
,2
]}

Kansakar, Urna ^{[1
,2
]}

Varzideh, Fahimeh ^{[1
,2
]}

Wilson, Scott ^{[1
]}

Mone, Pasquale ^{[1
]}

Lombardi, Angela ^{[1
]}

Gambardella, Jessica ^{[1
,2
,3
]}

Santulli, Gaetano ^{[1
,2
,3
]}

机构：

[1] Albert Einstein Coll Med, Einstein Mt Sinai Diabet Res Ctr ES DRC, Fleischer Inst Diabet & Metab FIDAM, Dept Med, New York, NY 10461 USA

[2] Albert Einstein Coll Med, Einstein Inst Aging Res, Wilf Family Cardiovasc Res Inst, Dept Mol Pharmacol,Einstein Inst Neuroimmunol & I, New York, NY 10461 USA

[3] Univ Naples Federico II, Dept Adv Biomed Sci, Int Translat Res & Med Educ ITME, I-80131 Naples, Italy

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 2021年 / 125卷

基金：

美国国家卫生研究院;

关键词：

Heart failure; Diabetic cardiomyopathy; Bioenergetics; Diabetes mellitus; Cardiovascular endocrinology; T2DM; T1DM; Oxidative stress; Fibroblasts; HFpEF; Senescence; Mitochondria; VSMC; Cardiomyocytes; ROS; Fibrosis; Aging; Diastolic dysfunction; Endothelium; NADH; BHB; FOX01; Adrenergic receptors; SMOOTH-MUSCLE-CELLS; PRESERVED EJECTION FRACTION; FATTY-ACID OXIDATION; CARDIAC ENERGY-METABOLISM; GLYCATION END-PRODUCTS; MATRIX-METALLOPROTEINASE ACTIVITY; MYOCARDIAL SUBSTRATE METABOLISM; KINASE-C ACTIVATION; DIASTOLIC DYSFUNCTION; PROTEIN-KINASE;

D O I：

10.1016/j.metabol.2021.154910

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heart failure and cardiovascular disorders represent the leading cause of death in diabetic patients. Here we present a systematic review of the main mechanisms underlying the development of diabetic cardiomyopathy. We also provide an excursus on the relative contribution of cardiomyocytes, fibroblasts, endothelial and smooth muscle cells to the pathophysiology of heart failure in diabetes. After having described the preclinical tools currently available to dissect the mechanisms of this complex disease, we conclude with a section on the most recent updates of the literature on clinical management. (C) 2021 Elsevier Inc. All rights reserved.

引用

页数：18

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