Ring transformation and antimicrobial activity of indolyl-substituted 2(3H)-furanones

被引：22
作者：
Abou-Elmagd, Wael S. I. [1 ]
El-Ziaty, Ahmed K. [1 ]
Abdalha, Abdelaal A. [1 ,2 ]
机构：
[1] Ain Shams Univ, Fac Sci, Dept Chem, Cairo 11566, Egypt
[2] Tabuk Univ, Dept Chem, Tabuk, Saudi Arabia
来源：
HETEROCYCLIC COMMUNICATIONS | 2015年 / 21卷 / 03期
关键词：
2(3H)-furanone; indole; oxadiazole; pyridazinone; triazole; HETEROCYCLIC-SYSTEMS; DERIVATIVES; CONVERSION; BEARING;
D O I：
10.1515/hc-2015-0008
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A variety of heterocycles of synthetic and biological importance were prepared from 3-(indol-3-yl-methylene)-5-phenyl-2(3H)-furanone (1) and its hydrazide 2. Compounds 1 and 2 were used for the construction of pyridazin-3(4H)-ones 4 and 6; 1,3,4-oxadiazoles 7, 8, and 10; and 1,2,4-triazoles 12, 14, and 15, all bearing a 3-indolyl moiety. The antimicrobial activities of the synthesized compounds were examined against six types of bacteria and two types of fungi.
引用
收藏
页码：179 / 185
页数：7
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