Transition Metal-Catalyzed C-H Bond Functionalizations by Use of Sulfur-Containing Directing Groups

被引：81

作者：

Tang, Kai-Xiang ^{[1
]}

Wang, Chun-Meng ^{[1
]}

Gao, Tian-Hong ^{[1
]}

Chen, Lin ^{[1
]}

Fan, Lian ^{[1
]}

Sun, Li-Ping ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Med Chem, Jiangsu Key Lab Drug Design & Optimizat, 24 Tongjiaxiang, Nanjing 210009, Jiangsu, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2019年 / 361卷 / 01期

关键词：

C-H bond functionalization; directing groups; sulfur-containing functional groups; synthetic methods; transition metals; SULFINYL ANILINE; ORTHO-OLEFINATION; ALPHA-ARYLATION; PALLADIUM; THIOETHERS; SULFOXIDES; ACTIVATION; ALKYLATION; ALKENYLATION; SULFONAMIDE;

D O I：

10.1002/adsc.201800484

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Transition metal-catalyzed direct functionalization of C-H bonds is an economical and efficient way to construct complex molecules that is currently attracting tremendous attention. In particular, the strategy involving transition metal-catalyzed regioselective C-H activation assisted by sulfur-containing directing groups has been realized in the past few years in spite of sulfur's ability to poison many transition metal catalysts. This review describes the rational development of sulfur-containing directing groups including thioethers, sulfoxides, thioamides, alkoxythiocarbonyl groups, and thioketones. Through collective efforts in the community, a range of transition metal-catalyzed C-H activation transformations using this type of directing group has been developed.

引用

页码：26 / 38

页数：13

共 83 条

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