The association of de novo anti-HLA-DPB1 donor-specific antibody formation and primary graft failure after allogeneic hematopoietic cell transplantation

被引：9
作者：
Hefazi, Mehrdad [1 ]
Hogan, William J. [1 ]
Wakefield, Laurie L. [2 ]
Gandhi, Manish J. [2 ]
机构：
[1] Mayo Clin, Div Hematol, Rochester, MN USA
[2] Mayo Clin, Div Transfus Med, Rochester, MN USA
来源：
HUMAN IMMUNOLOGY | 2018年 / 79卷 / 12期
关键词：
Hematopoietic cell transplantation; Allogeneic; Human Leukocyte Antigen; Donor Specific Antibody; Graft failure; HLA ANTIBODIES; SURVIVAL; IMPACT;
D O I：
10.1016/j.humimm.2018.08.009
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Despite advances in HLA matching, graft failure remains a serious complication after allogeneic hematopoietic cell transplantation (HCT). Pre-formed anti-HLA donor-specific antibodies (DSAs) have been associated with graft failure, but the impact of newly developing (de novo) anti-HLA antibodies on HCT outcomes remains unknown. Here, we present the first reported case of graft failure associated with de novo anti-HLA-DPB1 DSA after a 10/10 matched unrelated donor HCT. Based on this observation, testing for DSA should be considered in case of unexplained pancytopenia after allogeneic transplantation, especially after reduced intensity conditioning.
引用
收藏
页码：861 / 864
页数：4
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