Sezary Syndrome in a 17-Year-Old Boy: Clinicopathologic Features and Genomic Profile

被引：3

作者：

Alberti-Violetti, Silvia ^{[1
]}

Vezzoli, Pamela ^{[2
]}

Corti, Laura ^{[1
]}

Fanoni, Daniele ^{[1
]}

Merlo, Valentina ^{[1
]}

Venegoni, Luigia ^{[3
]}

Reseghetti, Alberto ^{[2
]}

Berti, Emilio ^{[1
,4
]}

机构：

[1] Osped Maggiore Policlin, Unita Operat Complessa Dermatol, Fdn Ist Ricovero & Cura Carattere Sci Ca Granda, Milan, Italy

[2] Azienda Sociosanit Terr Papa Giovanni XXIII, Unita Strutturale Complessa Dermatol, Bergamo, Italy

[3] Univ Milan, Dipartimento Fisiopatol Med Chirurg & Trapianti, Milan, Italy

[4] Univ Milano Bicocca, Dipartimento Sci Salute, Milan, Italy

来源：

PEDIATRIC DERMATOLOGY | 2016年 / 33卷 / 05期

关键词：

CUTANEOUS-LYMPHOMAS; MYCOSIS-FUNGOIDES;

D O I：

10.1111/pde.12930

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

We describe the case of a 17-year-old Hispanic boy who had had erythroderma and diffuse lymphadenopathy for approximately 6 months. A diagnosis of Sezary syndrome was made on the basis of the histologic features of the skin; the presence of the same T-cell clone on the skin, blood, and bone marrow; and the high CD4(+) lymphocyte count with an aberrant phenotype in peripheral blood; bone marrow involvement was also present. The patient was treated with systemic gemcitabine and achieved partial remission.

引用

页码：E318 / E321

页数：4

共 15 条

[1]

Alberti-Violetti Silvia, 2015, Clin Lymphoma Myeloma Leuk, V15, pe105, DOI 10.1016/j.clml.2015.02.027

[2] Cutaneous lymphoma incidence patterns in the United States: a population-based study of 3884 cases [J].

Bradford, Porcia T. ;

Devesa, Susan S. ;

Anderson, William F. ;

Toro, Jorge R. .

BLOOD, 2009, 113 (21) :5064-5073

[3] Identification of Key Regions and Genes Important in the Pathogenesis of Sezary Syndrome by Combining Genomic and Expression Microarrays [J].

Caprini, Elisabetta ;

Cristofoletti, Cristina ;

Arcelli, Diego ;

Fadda, Paolo ;

Citterich, Mauro Helmer ;

Sampogna, Francesca ;

Magrelli, Armando ;

Censi, Federica ;

Torreri, Paola ;

Frontani, Marina ;

Scala, Enrico ;

Picchio, Maria Cristina ;

Temperani, Paola ;

Monopoli, Alessandro ;

Lombardo, Giuseppe Alfonso ;

Taruscio, Domenica ;

Narducci, Maria Grazia ;

Russo, Giandomenico .

CANCER RESEARCH, 2009, 69 (21) :8438-8446

[4] Genomic landscape of cutaneous T cell lymphoma [J].

Choi, Jaehyuk ;

Goh, Gerald ;

Walradt, Trent ;

Hong, Bok S. ;

Bunick, Christopher G. ;

Chen, Kan ;

Bjornson, Robert D. ;

Maman, Yaakov ;

Wang, Tiffany ;

Tordoff, Jesse ;

Carlson, Kacie ;

Overton, John D. ;

Liu, Kristina J. ;

Lewis, Julia M. ;

Devine, Lesley ;

Barbarotta, Lisa ;

Foss, Francine M. ;

Subtil, Antonio ;

Vonderheid, Eric C. ;

Edelson, Richard L. ;

Schatz, David G. ;

Boggon, Titus J. ;

Girardi, Michael ;

Lifton, Richard P. .

NATURE GENETICS, 2015, 47 (09) :1011-+

[5]

Espinet Blanca, 2013, Methods Mol Biol, V973, P175, DOI 10.1007/978-1-62703-281-0_11

[6] Paediatric cutaneous lymphomas: a review and comparison with adult counterparts [J].

Kempf, W. ;

Kazakov, D. V. ;

Belousova, I. E. ;

Mitteldorf, C. ;

Kerl, K. .

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2015, 29 (09) :1696-1709

[7] SEZARY-SYNDROME IN AN 11-YEAR-OLD GIRL [J].

MEISTER, L ;

DUARTE, AM ;

DAVIS, J ;

PEREZ, JL ;

SCHACHNER, LA .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1993, 28 (01) :93-95

[8] Revisions to the staging and classification of mycosis fungoides and Sezary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC) [J].

Olsen, Elise ;

Vonderheid, Eric ;

Pimpinelli, Nicola ;

Willemze, Rein ;

Kim, Youn ;

Knobler, Robert ;

Zackheim, Herschel ;

Duvic, Madeleine ;

Estrach, Teresa ;

Lamberg, Stanford ;

Wood, Gary ;

Dummer, Reinhard ;

Ranki, Annamari ;

Burg, Gunter ;

Heald, Peter ;

Pittelkow, Mark ;

Bernengo, Maria-Grazia ;

Sterry, Wolfram ;

Laroche, Liliane ;

Trautinger, Franz ;

Whittaker, Sean .

BLOOD, 2007, 110 (06) :1713-1722

[9] Allelotyping in mycosis fungoides and Sezary syndrome: Common regions of allelic loss identified on 9p, 10q, and 17p [J].

Scarisbrick, JJ ;

Woolford, AJ ;

Russell-Jones, R ;

Whittaker, SJ .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2001, 117 (03) :663-670

[10] Trends in Incidence of Primary Cutaneous Malignancies in Children, Adolescents, and Young Adults: A Population-Based Study [J].

Senerchia, Andreza A. ;

Ribeiro, Karina B. ;

Rodriguez-Galindo, Carlos .

PEDIATRIC BLOOD & CANCER, 2014, 61 (02) :211-216

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