Characteristics of Oxidative Stress in Experimental Rat Brain Ischemia Aggravated by Homocysteic Acid

被引：8

作者：

Dobrotvorskaya, I. S. ^{[1
,2
]}

Fedorova, T. N. ^{[2
]}

Dobrota, D. ^{[3
]}

Berezov, T. T. ^{[1
]}

机构：

[1] Russian Acad Med Sci, Inst Biomed Chem, Lab Biochem Amines & Cycl Nucleotides, Moscow, Russia

[2] Russian Acad Med Sci, Lab Clin & Expt Neurochem, Res Ctr Neurol, Moscow, Russia

[3] Comenius Univ, Dept Med Biochem, Jesseinus Fac Med, Martin, Slovakia

来源：

NEUROCHEMICAL JOURNAL | 2011年 / 5卷 / 01期

基金：

俄罗斯基础研究基金会;

关键词：

global brain ischemia; homocysteine; oxidative stress; carnosine; Win5521-2; GLUTAMATE RECEPTORS;

D O I：

10.1134/S1819712410041014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We developed a new experimental model of oxidative stress in rats, which combines the effects of 3-vessel brain ischemia and an increased level of homocysteine in blood circulation. We compared the protective effects of two compounds, the agonist of cannabinoid receptors Win5521-2 and the natural antioxidant carnosine. We found that Win5521-2 has a protective effect only at a normal blood level of homocysteine, whereas carnosine is also effective under conditions of elevated homocysteine level.

引用

页码：42 / 46

页数：5

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