Second primary malignancy risk in thyroid cancer survivors: A systematic review and meta-analysis

被引：113

作者：

Subramanian, Shoba ^{[2
]}

Goldstein, David P. ^{[3
,4
]}

Parlea, Luciana ^{[4
]}

Thabane, Lehana ^{[5
,6
]}

Ezzat, Shereen ^{[1
,7
,8
,9
]}

Ibrahim-Zada, Irada ^{[10
]}

Straus, Sharon ^{[11
,12
]}

Brierley, James D. ^{[4
,13
]}

Tsang, Richard W. ^{[13
]}

Gafni, Amiram ^{[5
,14
]}

Rotstein, Lorne ^{[4
,15
]}

Sawka, Anna M. ^{[1
,16
]}

机构：

[1] Toronto Gen Hosp, Dept Med, Div Endocrinol, Toronto, ON M5G 2C4, Canada

[2] Stanford Univ, Palo Alto, CA 94304 USA

[3] Univ Hlth Network, Dept Otolaryngol Head & Neck Surg, Toronto, ON, Canada

[4] Univ Toronto, Toronto, ON, Canada

[5] McMaster Univ, Dept Clin Epidemiol & Biostat, Hamilton, ON, Canada

[6] St Josephs Healthcare, Ctr Evaluat Med, Hamilton, ON, Canada

[7] Mt Sinai Hosp, Dept Med, Div Endocrinol, Toronto, ON M5G 1X5, Canada

[8] Freeman Ctr Endocrine Oncol, Toronto, ON, Canada

[9] Ontario Canc Inst, Toronto, ON M4X 1K9, Canada

[10] Univ Hlth Networ, Dept Med, Div Endocrinol, Toronto, ON, Canada

[11] Univ Toronto, Deot Knowledge Translat, Toronto, ON, Canada

[12] Univ Calgary, Dept Med, Dept Geriatr, Calgary, AB, Canada

[13] Univ Hlth Network, Dept Radiat Oncol, Toronto, ON, Canada

[14] McMaster Univ, Ctr Hlth Econ & Policy Anal, Hamilton, ON, Canada

[15] Univ Hlth Network, Dept Surg, Toronto, ON, Canada

[16] Univ Hlth Network, Dept Med, Div Endocrinol, Toronto, ON, Canada

来源：

THYROID | 2007年 / 17卷 / 12期

关键词：

D O I：

10.1089/thy.2007.0171

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: To determine the risk of second primary malignancies (SPMs) in thyroid cancer survivors. Design: We performed a systematic review and meta-analysis examining the standardized incidence ratios (SIRs) of SPMs in thyroid cancer survivors (compared to individuals without thyroid cancer). Two independent reviewers screened citations and reviewed all full-text papers deemed potentially relevant. Final consensus was reached on inclusion of papers in the review. Data were pooled using fixed effects models. Main outcomes: Thirteen full-text papers were included. The incidence of SPMs in thyroid cancer survivors was increased with an SIR of 1.20 (95% confidence interval 1.17, 1.24) (based on pooled data from six studies of 70,844 thyroid cancer survivors). The SIR of the following SPMs was significantly increased: salivary gland, stomach, colon/colorectal, breast, prostate, kidney, brain/central nervous system, soft tissue sarcoma, non-Hodgkin's lymphoma, multiple myeloma, leukemia, bone/joints, and adrenal. A significantly reduced risk of lung and cervical cancers was observed. Conclusions: Thyroid cancer survivors are at increased risk of SPMs, which may be related to disease-specific treatments or genetic predisposition.

引用

页码：1277 / 1288

页数：12

共 45 条

[1] The risk of multiple primary breast and thyroid carcinomas -: Role of the radiation dose [J].

Adjadj, E ;

Rubino, C ;

Shamsaldim, A ;

Lê, MG ;

Schlumberger, M ;

de Vathaire, F .

CANCER, 2003, 98 (06) :1309-1317

[2] 2ND MALIGNANCIES IN THYROID-CANCER PATIENTS - A POPULATION-BASED SURVEY OF 3658 CASES FROM NORWAY [J].

AKSLEN, LA ;

GLATTRE, E .

EUROPEAN JOURNAL OF CANCER, 1992, 28A (2-3) :491-495

[3]

[Anonymous], 2005, CAN CANC STAT

[4] Risk of second primary cancer following differentiated thyroid cancer [J].

Berthe, E ;

Henry-Amar, M ;

Michels, JJ ;

Rame, JP ;

Berthet, P ;

Babin, E ;

Icard, P ;

Samama, G ;

Galateau-Sallé, F ;

Mahoudeau, J ;

Bardet, S .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2004, 31 (05) :685-691

[5] INDUCTION OF LEUKEMIA BY I-131 TREATMENT OF THYROID-CARCINOMA [J].

BRINCKER, H ;

HANSEN, HS ;

ANDERSEN, AP .

BRITISH JOURNAL OF CANCER, 1973, 28 (03) :232-237

[6] RADIOIODINE TREATMENT OF METASTATIC THYROID-CARCINOMA - THE ROYAL-MARSDEN-HOSPITAL EXPERIENCE [J].

BROWN, AP ;

GREENING, WP ;

MCCREADY, VR ;

SHAW, HJ ;

HARMER, CL .

BRITISH JOURNAL OF RADIOLOGY, 1984, 57 (676) :323-327

[7] Risk of second primary malignancies in women with papillary thyroid cancer [J].

Canchola, AJ ;

Horn-Ross, PL ;

Purdie, DM .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2006, 163 (06) :521-527

[8]

Chen AY, 2001, CANCER-AM CANCER SOC, V92, P225, DOI 10.1002/1097-0142(20010715)92:2<225::AID-CNCR1313>3.0.CO

[9]

2-B

[10] Radiotherapy for primary thyroid cancer as a risk factor for second primary cancers [J].

Chuang, Shu-Chun ;

Hashibe, Mia ;

Yu, Guo-Pei ;

Le, Anh D. ;

Cao, Wei ;

Hurwitz, Eric L. ;

Rao, Jian-Yu ;

Neugut, Alfred I. ;

Zhang, Zuo-Feng .

CANCER LETTERS, 2006, 238 (01) :42-52

← 1 2 3 4 5 →