Concise Synthesis of a Cyclopentane Intermediate Possessing All Nitrogen Functionalities for Pactamycin

被引：6

作者：

Matsumoto, Nobuyuki ^{[1
]}

Nakazaki, Atsuo ^{[1
]}

Nishikawa, Toshio ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Bioagr Sci, Chikusa Ku, Nagoya, Aichi 4648601, Japan

来源：

SYNLETT | 2017年 / 28卷 / 17期

关键词：

natural product synthesis; pactamycin; aminocyclopentitol; oxime-olefin cycloaddition; aziridines; 30S RIBOSOMAL-SUBUNIT; L-GLUCOSE; ANTITUMOR; CORE; ANALOGS; CYCLOADDITION; CONSTRUCTION; INHIBITION; JOGYAMYCIN; ACCESS;

D O I：

10.1055/s-0036-1588495

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pactamycin, a potent antitumor and antimicrobial antibiotic, possesses a densely functionalized cyclopentane core structure. This paper describes the concise synthesis of an advanced intermediate for synthesizing the enantiomer of pactamycin that contains the cyclopentane skeleton bearing all the necessary amino functions with correct stereochemistries.

引用

页码：2303 / 2306

页数：4

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