Prevalence of paediatric hyperinflammatory conditions in paediatric and adolescent hospitalized COVID-19 patients: a systematic review and meta-analysis

被引:5
作者
Sharma, Divyansh [1 ,2 ,3 ]
Bhaskar, Sonu M. M. [2 ,3 ,4 ,5 ,6 ]
机构
[1] Univ New South Wales UNSW, South Western Sydney Clin Sch, Sydney, NSW, Australia
[2] Ingham Inst Appl Med Res, Neurovasc Imaging Lab, Clin Sci Stream, Sydney, NSW, Australia
[3] Global Hlth Neurol & Translat Neurosci Lab, Sydney, NSW, Australia
[4] NSW Hlth Pathol, NSW Brain Clot Bank, Sydney, NSW, Australia
[5] Liverpool Hosp, Dept Neurol & Neurophysiol, Neurophysiol Level 1,Clin Sci Bldg,Elizabeth St, Sydney, NSW 2170, Australia
[6] South Western Sydney Local Hlth Dist, Sydney, NSW, Australia
关键词
COVID-19; immunology; Kawasaki disease; MIS-C; prevalence; MULTISYSTEM INFLAMMATORY SYNDROME; CLINICAL CHARACTERISTICS; SARS-COV-2; INFECTION; CHILDREN; DISEASE; UK;
D O I
10.1111/apm.13199
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In the milieu of coronavirus disease 2019 (COVID-19), there are increasing reports of paediatric hyperinflammatory conditions (PHICs), including multisystem inflammatory syndrome in children (MIS-C), paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS) and Kawasaki disease (KD). Few analyses of PHIC prevalence in paediatric and adolescent hospitalized COVID-19 patients exist. The purpose of this study was to perform a meta-analysis to determine a pooled prevalence estimate of PHICs in paediatric and adolescent hospitalized patients admitted for treatment due to COVID-19. Individual studies were retrieved from PubMed/Medline, EMBASE and Cochrane databases. Relevant prevalence, baseline, treatment and outcome data were extracted using a standardized datasheet. The systematic review and meta-analysis were conducted as per the PRISMA and MOOSE guidelines. Overall, 14 studies with 2202 patients admitted for treatment due to COVID-19, among whom 780 were diagnosed with PHICs, were included. The crude estimate of prevalence was 35.42%, and the pooled estimate of prevalence was 29% (random pooled ES = 0.29; 95% CIs = 0.18-0.42; p < 0.0001; z = 7.45). A sizeable proportion of paediatric and adolescent hospitalized patients admitted for treatment due to COVID-19 are diagnosed with a PHIC warranting a high index of clinical suspicion for PHICs. Further studies are required to validate these findings.
引用
收藏
页码:101 / 110
页数:10
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