Biomarkers of Liver Injury during Transplantation in an Era of Machine Perfusion

被引：25
作者：
Bhogal, Ricky H. [1 ,2 ,3 ,4 ]
Mirza, Darius F. [1 ,2 ,3 ,5 ]
Afford, Simon C. [1 ,2 ,3 ]
Mergental, Hynek [1 ,2 ,3 ,5 ]
机构：
[1] Univ Birmingham, Birmingham Biomed Res Ctr, Natl Inst Hlth Res, Birmingham B15 2TT, W Midlands, England
[2] Univ Hosp Birmingham NHS Fdn Trust, Birmingham B15 2TT, W Midlands, England
[3] Univ Birmingham, Inst Immunol & Immunotherapy, Ctr Liver & Gastrointestinal Res, Birmingham B15 2TT, W Midlands, England
[4] Royal Marsden Hosp NHS Fdn Trust, London SW3 6JJ, England
[5] Univ Hosp Birmingham NHS Fdn Trust, Queen Elizabeth Hosp, Liver Unit, Birmingham B15 2TH, W Midlands, England
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 05期
基金：
英国惠康基金;
关键词：
liver transplantation; ischaemia-reperfusion injury; biomarkers; machine perfusion; ISCHEMIA-REPERFUSION INJURY; EARLY ALLOGRAFT DYSFUNCTION; FUNCTIONAL ASSESSMENT; MODEL; DONATION; CRITERIA; DEATH; HEMODYNAMICS; PRESERVATION; INFLAMMATION;
D O I：
10.3390/ijms21051578
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Liver ischaemia-reperfusion injury (IRI) is an intrinsic part of the transplantation process and damages the parenchymal cells of the liver including hepatocytes, endothelial cells and cholangiocytes. Many biomarkers of IRI have been described over the past two decades that have attempted to quantify the extent of IRI involving different hepatic cellular compartments, with the aim to allow clinicians to predict the suitability of donor livers for transplantation. The advent of machine perfusion has added an additional layer of complexity to this field and has forced researchers to re-evaluate the utility of IRI biomarkers in different machine preservation techniques. In this review, we summarise the current understanding of liver IRI biomarkers and discuss them in the context of machine perfusion.
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页数：12
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