Sporadic Medullary Thyroid Carcinoma with Paraneoplastic Cushing Syndrome

被引：3

作者：

Pivovarova, Aleksandra I. ^{[1
,2
]}

Patrick, Stephanie ^{[1
,3
]}

Reddy, Punuru J. ^{[4
]}

机构：

[1] Alabama Coll Osteopath Med, 445 Hlth Sci Blvd, Dothan, AL 36303 USA

[2] Univ Mississippi, Med Ctr, 2500 N State St, Jackson, MS 39216 USA

[3] Univ Tennessee, Hlth Sci Ctr, 910 Madison Ave, Memphis, TN 38163 USA

[4] Decatur Morgan Hosp, Dept Internal Med, 1201 7th St SE, Decatur, AL 35601 USA

来源：

CASE REPORTS IN ENDOCRINOLOGY | 2019年 / 2019卷

关键词：

VANDETANIB; MANAGEMENT; PATIENT; HYPERCORTISOLISM; CANCER;

D O I：

10.1155/2019/6414921

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Medullary thyroid cancer (MTC) is a rare form of neoplasm affecting the thyroid gland. This neuroendocrine tumor is capable of releasing active substances causing systemic manifestation in the form of flushing, diarrhea, and uncommonly, Ectopic Cushing's syndrome (ECS). MTC can be hereditary as a part of multiple endocrine neoplasm type 2 syndrome (MEN2) or arise sporadically. We report a case of a 74-year-old female presenting with chronic diarrhea, in whom diagnosis of sporadic MTC was delayed due to previous history of gastrointestinal (GI) disturbances. The patient developed liver metastases yielding ACTH dependent Cushing's Syndrome leading to abnormal clinical presentation and laboratory values driven by elevated cortisol level. Metastatic MTC should be considered in patients presenting with chronic diarrhea and weakness unexplained by other GI related causes.

引用

页数：4

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