A tripeptidyl ensemble perspective of interactive control of growth hormone secretion

被引：11
作者：
Veldhuis, JD [1 ]
机构：
[1] Mayo Clin & Mayo Fdn, Mayo Med & Grad Sch Med, Gen Clin Res Ctr, Dept Internal Med, Rochester, MN 55905 USA
来源：
HORMONE RESEARCH | 2003年 / 60卷
关键词：
growth hormone; growth hormone-releasing hormone; growth hormone-releasing peptide; ghrelin; somatostatin; insulin-like growth factor I; threefold peptide control pathway; sex-steroid hormones; gender; oestrogen; oestradiol; women;
D O I：
10.1159/000071232
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Current investigational tools in molecular biology, biochemistry and integrative physiology have revealed an increasing array of signals that influence growth hormone (GH) secretion. The present perspective combines these factors under a simplified final-common pathway model of threefold joint control by GH-releasing hormone, GH-releasing peptide/ghrelin and somatostatin. This concept is highlighted from the viewpoint of sex steroid- and age-dependent modulation of the peptide trilogy listed above. Copyright (C) 2003 S. Karger AG, Basel.
引用
收藏
页码：86 / 101
页数：16
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