Densitometric determination of desloratadine in tablets, and validation of the method

A simple and rapid densitometric method has been developed for determination of desloratadine in tablets. After extraction of the samples with 96% ethanol the: solutions were spotted on precoated silica gel TLC plates and these were eluted with ethyl acetate-n-butanol-25% aqueous ammonia-methanol, 21 + 5.0 + 4.0 + 5.0 (v/v), as mobile phase. Quantitative evaluation was performed by measuring the absorbance reflectance of the desloratadine spots at, lambda = 279 nm. The TLC-densitometric method is selective, precise, and accurate and can be used for routine analysis of tablets in pharmaceutical industry quality control laboratories.