Idiopathic Pulmonary Fibrosis: Pathogenesis and the Emerging Role of Long Non-Coding RNAs

被引:53
作者
Hadjicharalambous, Marina R. [1 ]
Lindsay, Mark A. [1 ]
机构
[1] Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England
基金
英国生物技术与生命科学研究理事会;
关键词
long non-coding RNAs; lncRNAs; fibrosis; lung; IPF; ALVEOLAR EPITHELIAL-CELLS; GENE-EXPRESSION; MESSENGER-RNA; GROWTH-FACTOR; TGF-BETA; TRANSFORMING GROWTH-FACTOR-BETA-1; MESENCHYMAL TRANSITION; MOLECULAR-MECHANISMS; X-INACTIVATION; LUNG INJURY;
D O I
10.3390/ijms21020524
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Idiopathic pulmonary fibrosis (IPF) is a progressive chronic disease characterized by excessing scarring of the lungs leading to irreversible decline in lung function. The aetiology and pathogenesis of the disease are still unclear, although lung fibroblast and epithelial cell activation, as well as the secretion of fibrotic and inflammatory mediators, have been strongly associated with the development and progression of IPF. Significantly, long non-coding RNAs (lncRNAs) are emerging as modulators of multiple biological processes, although their function and mechanism of action in IPF is poorly understood. LncRNAs have been shown to be important regulators of several diseases and their aberrant expression has been linked to the pathophysiology of fibrosis including IPF. This review will provide an overview of this emerging role of lncRNAs in the development of IPF.
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页数:19
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共 140 条
[1]   Short telomeres are a risk factor for idiopathic pulmonary fibrosis [J].
Alder, Jonathan K. ;
Chen, Julian J. -L. ;
Lancaster, Lisa ;
Danoff, Sonye ;
Su, Shu-Chih ;
Cogan, Joy D. ;
Vulto, Irma ;
Xie, Mingyi ;
Qi, Xiaodong ;
Tuder, Rubin M. ;
Phillips, John A., III ;
Lansdorp, Peter M. ;
Loyd, James E. ;
Armanios, Mary Y. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (35) :13051-13056
[2]   Growth factors in idiopathic pulmonary fibrosis: relative roles [J].
Allen, JT ;
Spiteri, MA .
RESPIRATORY RESEARCH, 2001, 3 (01)
[3]   PLATELET-DERIVED GROWTH-FACTOR IN IDIOPATHIC PULMONARY FIBROSIS [J].
ANTONIADES, HN ;
BRAVO, MA ;
AVILA, RE ;
GALANOPOULOS, T ;
NEVILLEGOLDEN, J ;
MAXWELL, M ;
SELMAN, M .
JOURNAL OF CLINICAL INVESTIGATION, 1990, 86 (04) :1055-1064
[4]   EXPRESSION OF MONOCYTE CHEMOATTRACTANT PROTEIN-1 MESSENGER-RNA IN HUMAN IDIOPATHIC PULMONARY FIBROSIS [J].
ANTONIADES, HN ;
NEVILLEGOLDEN, J ;
GALANOPOULOS, T ;
KRADIN, RL ;
VALENTE, AJ ;
GRAVES, DT .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (12) :5371-5375
[5]   Telomerase mutations in families with idiopathic pulmonary fibrosis [J].
Armanios, Mary Y. ;
Chen, Julian J. -L. ;
Cogan, Joy D. ;
Alder, Jonathan K. ;
Ingersoll, Roxann G. ;
Markin, Cheryl ;
Lawson, William E. ;
Xie, Mingyi ;
Vulto, Irma ;
Phillips, John A., III ;
Lansdorp, Peter M. ;
Greider, Carol W. ;
Loyd, James E. .
NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (13) :1317-1326
[6]   Therapeutic Targeting of Long Non-Coding RNAs in Cancer [J].
Arun, Gayatri ;
Diermeier, Sarah D. ;
Spector, David L. .
TRENDS IN MOLECULAR MEDICINE, 2018, 24 (03) :257-277
[7]   Immune Inflammation and Disease Progression in Idiopathic Pulmonary Fibrosis [J].
Balestro, Elisabetta ;
Calabrese, Fiorella ;
Turato, Graziella ;
Lunardi, Francesca ;
Bazzan, Erica ;
Marulli, Giuseppe ;
Biondini, Davide ;
Rossi, Emanuela ;
Sanduzzi, Alessandro ;
Rea, Federico ;
Rigobello, Chiara ;
Gregori, Dario ;
Baraldo, Simonetta ;
Spagnolo, Paolo ;
Cosio, Manuel G. ;
Saetta, Marina .
PLOS ONE, 2016, 11 (05)
[8]  
Baroni GS, 1996, HEPATOLOGY, V23, P1189
[9]   Liver fibrosis [J].
Bataller, R ;
Brenner, DA .
JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (02) :209-218
[10]   A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition [J].
Beltran, Manuel ;
Puig, Isabel ;
Pena, Cristina ;
Miguel Garcia, Jose ;
Belen Alvarez, Ana ;
Pena, Raul ;
Bonilla, Felix ;
Garcia de Herreros, Antonio .
GENES & DEVELOPMENT, 2008, 22 (06) :756-769