Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition

被引：97

作者：

Joyner, P. Matthew ^{[1
]}

Liu, Jinman ^{[2
]}

Zhang, Zhijun ^{[2
]}

Merritt, Justin ^{[2
]}

Qi, Fengxia ^{[2
]}

Cichewicz, Robert H. ^{[1
,3
]}

机构：

[1] Univ Oklahoma, Stephenson Life Sci Res Ctr, Nat Prod Discovery Grp, Dept Chem & Biochem, Norman, OK 73019 USA

[2] Univ Oklahoma, Hlth Sci Ctr, Coll Dent, Oklahoma City, OK 73014 USA

[3] Univ Oklahoma, Grad Program Ecol & Evolutionary Biol, Norman, OK 73019 USA

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2010年 / 8卷 / 24期

基金：

美国国家卫生研究院;

关键词：

BACTERIAL; BIOSYNTHESIS;

D O I：

10.1039/c0ob00579g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The recent investigation of a gene cluster encoding for a hybrid PKS-NRPS metabolite in the oral pathogen Streptococcus mutans UA159 yielded evidence that this natural product might play an important role regulating a range of stress tolerance factors. We have now characterized the major compound generated from this gene cluster, mutanobactin A, and demonstrated that this secondary metabolite is also capable of influencing the yeast-mycelium transition of Candida albicans.

引用

页码：5486 / 5489

页数：4

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