Synthesis, antimicrobial activity and molecular docking of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized oxygen heterocycles

被引：26

作者：

Dongamanti, Ashok ^{[1
]}

Aamate, Vikas Kumar ^{[1
]}

Devulapally, Mohan Gandhi ^{[1
]}

Gundu, Srinivas ^{[1
]}

Kotni, Meena Kumari ^{[2
]}

Manga, Vijjulatha ^{[2
]}

Balasubramanian, Sridhar ^{[3
]}

Ernala, Prasad ^{[4
]}

机构：

[1] Osmania Univ, Dept Chem, Hyderabad 500007, Andhra Pradesh, India

[2] Osmania Univ, Dept Chem, Univ Coll Sci, Mol Modeling & Med Chem Grp, Hyderabad 500007, Andhra Pradesh, India

[3] Indian Inst Chem Technol, Lab Xray, CSIR, Hyderabad 500007, Andhra Pradesh, India

[4] Indian Inst Chem Technol, Med Chem & Pharmacol Div, CSIR, Hyderabad 500007, Andhra Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2015年 / 25卷 / 04期

关键词：

Flavonoid framework; Medium sized rings; Antimicrobial activity; Molecular docking;

D O I：

10.1016/j.bmcl.2014.12.066

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A convenient approach for the synthesis of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized heterocyclic rings (eight-, nine-, ten- and eleven-membered rings) containing two oxygen atoms from flavonols through alkylation using different dibromoalkanes was described. The synthesized compounds were established based on the spectral data and X-ray crystal structure for 6c. The synthesized compounds were evaluated for their in vitro antimicrobial activity. Docking studies were carried out for most active two compounds 6f and 6i. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：898 / 903

页数：6

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