Objective Assessment of Dermatitis Following Post-operative Radiotherapy in Patients with Breast Cancer Treated with Breast-conserving Treatment

被引:23
作者
Yoshida, Ken [2 ]
Yamazaki, Hideya [1 ]
Takenaka, Tadashi [2 ]
Tanaka, Eiichi [2 ]
Kotsuma, Tadayuki [3 ]
Fujita, Yuka [4 ]
Masuda, Norikazu [5 ]
Kuriyama, Keiko [2 ]
Yoshida, Mineo [2 ]
Nishimura, Tsunehiko
机构
[1] Kyoto Prefectural Univ Med, Dept Radiol, Kamigyo Ku, Kyoto 6028566, Japan
[2] Natl Hosp Org Osaka Natl Hosp, Dept Radiol, Osaka, Japan
[3] Osaka Univ, Grad Sch Med, Dept Radiat Oncol, Osaka, Japan
[4] Osaka Univ, Grad Sch Med, Dept Diagnost & Intervent Radiol, Osaka, Japan
[5] Natl Hosp Org Osaka Natl Hosp, Dept Surg, Osaka, Japan
关键词
Breast cancer; Radiation dermatitis; Breast conservative treatment; Corneometer; Spectrophotometer; RADIATION-THERAPY; IRRADIATION; TOXICITY; ERYTHEMA; COLOR;
D O I
10.1007/s00066-010-2134-1
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
To evaluate radiation dermatitis objectively in patients with breast cancer who had undergone post-operative radiotherapy after breast-conserving surgery. Skin color (L*, a*, and b* values) and moisture analyses were performed for both breasts (before, after, 1 month, 6 months, and 1 year after radiotherapy) to examine irradiated and non-irradiated skin divided into four quadrants in 118 patients. These patients underwent breast conservative surgery followed by 50 Gy/25 fractions (median) of radiotherapy with or without boost irradiation (10 Gy/5 fractions). L*, a*, and moisture values were changed by irradiation and maximized at completion or 1 month after radiotherapy. One year after radiotherapy, the skin color had returned to the range observed prior to radiotherapy. However, moisture did not return to previous values even 1 year after treatment. The lateral upper side (quadrant C) showed greater changes than other quadrants in the L* value (darker) at the end of radiotherapy. The Common Toxicity Criteria version 3 scores were found to correlate well with a* and L* values at the completion and 1 month after radiotherapy. Boost radiotherapy intensified reddish and darker color changes at the completion of radiotherapy, while chemotherapy did not intensify the skin reaction caused by radiotherapy. Moisture impairment as a result of irradiation lasts longer than color alterations. Objective assessments are useful for analyzing radiation dermatitis.
引用
收藏
页码:621 / 629
页数:9
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