Uptake of co-testing with HPV and cytology for cervical screening: A population-based evaluation in the United States

被引：13

作者：

Cuzick, Jack ^{[1
]}

Du, Ruofei ^{[2
]}

Adcock, Rachael ^{[1
]}

Kinney, Walter

Joste, Nancy ^{[3
]}

McDonald, Ruth M. ^{[3
,7
]}

English, Kevin ^{[4
]}

Torres, Salina M. ^{[5
]}

Saslow, Debbie ^{[6
]}

Wheeler, Cosette M. ^{[3
,7
]}

机构：

[1] Queen Mary Univ London, Ctr Canc Prevent, Wolfson Inst Prevent Med, London, England

[2] Univ New Mexico, Dept Internal Med, Div Mol Med, Comprehens Canc Ctr, Albuquerque, NM 87131 USA

[3] UNM Hlth Sci Ctr HSC, Dept Pathol, Albuquerque, NM USA

[4] Albuquerque Area Southwest Tribal Epidemiol Ctr, Albuquerque, NM USA

[5] New Mexico Dept Hlth, Albuquerque, NM USA

[6] Amer Canc Soc, Atlanta, GA 30329 USA

[7] Ctr HPV Prevent, UNM Comprehens Canc Ctr, Albuquerque, NM USA

来源：

GYNECOLOGIC ONCOLOGY | 2021年 / 162卷 / 03期

关键词：

AMERICAN-CANCER-SOCIETY; FOLLOW-UP; PREVENTION; NEOPLASIA; WOMEN; RISK;

D O I：

10.1016/j.ygyno.2021.06.029

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objectives. Human papillomavirus (HPV) testing for cervical screening has been shown to increase the yield of precancerous disease and reduce the incidence of cervical cancer more than cytology alone. Here we document the state-wide uptake of co-testing with HPV and cytology in women aged 30-64 years as recommended by na-tional and international bodies. Methods. Registry-based study of all screening cytology and HPV tests in New Mexico from 2008 to 2019 among women aged 21-64 years, with a focus on cytology negative tests to distinguish co-testing from reflex HPV testing to triage equivocal or mildly abnormal cytology. Results. A total of 1,704,055 cervical screening tests from 681,440 women aged 21-64 years in the state of New Mexico were identified. The proportion of screening tests which were co-tests rose from 5.6% in 2008 to 84.3% in 2019 among women aged 30-64 years with a marked change from the near exclusive use of the Hybrid Capture II HPV test, (a signal amplified test method) to the use of target amplified HPV tests. The largest increases were seen between 2013 and 2015, reflecting the introduction and adoption of new clinical guidelines. Increases in co-testing were also seen in younger women. Conclusions. Co-testing is now well established in women aged 30-64 years, but smaller increases have also been seen at younger ages, although this is not currently recommended. The impact of co-testing on cervical dis-ease outcomes and number of colposcopies and biopsies in routine population settings remain important, espe-cially in young women. (C) 2021 The Authors. Published by Elsevier Inc.

引用

页码：555 / 559

页数：5

共 18 条

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