Molecular mechanisms of fluoride toxicity

被引:826
作者
Barbier, Olivier [1 ]
Arreola-Mendoza, Laura [2 ]
Maria Del Razo, Luz [1 ]
机构
[1] Inst Politecn Nacl CINVESTAV IPN, Ctr Invest Estudios Avanzados, Mexico City 07360, DF, Mexico
[2] Inst Politecn Nacl CINVESTAV IPN, Ctr Interdisciplinario Invest & Estudios Sobre Me, Mexico City 07360, DF, Mexico
关键词
Fluoride toxicity; Oxidative stress; Gene regulation; Signal transduction; Fluorosis; Drinking water; GTP-BINDING PROTEINS; ENDOPLASMIC-RETICULUM STRESS; ACTIN-FILAMENT ORGANIZATION; TISSUE OXIDATIVE STRESS; EPITHELIAL LUNG-CELLS; SODIUM-FLUORIDE; IN-VITRO; INDUCED APOPTOSIS; DRINKING-WATER; ALZHEIMERS-DISEASE;
D O I
10.1016/j.cbi.2010.07.011
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Halfway through the twentieth century, fluoride piqued the interest of toxicologists due to its deleterious effects at high concentrations in human populations suffering from fluorosis and in in vivo experimental models. Until the 1990s, the toxicity of fluoride was largely ignored due to its "good reputation" for preventing caries via topical application and in dental toothpastes. However, in the last decade, interest in its undesirable effects has resurfaced due to the awareness that this element interacts with cellular systems even at low doses. In recent years, several investigations demonstrated that fluoride can induce oxidative stress and modulate intracellular redox homeostasis, lipid peroxidation and protein carbonyl content, as well as alter gene expression and cause apoptosis. Genes modulated by fluoride include those related to the stress response, metabolic enzymes, the cell cycle, cell-cell communications and signal transduction. The primary purpose of this review is to examine recent findings from our group and others that focus on the molecular mechanisms of the action of inorganic fluoride in several cellular processes with respect to potential physiological and toxicological implications. This review presents an overview of the current research on the molecular aspects of fluoride exposure with emphasis on biological targets and their possible mechanisms of involvement in fluoride cytotoxicity. The goal of this review is to enhance understanding of the mechanisms by which fluoride affects cells, with an emphasis on tissue-specific events in humans. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:319 / 333
页数:15
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