Impact of dyslipidemia on 24-h urine composition in adults without urolithiasis

PurposesTo evaluate the influence of dyslipidemia on 24-h urine composition in adults who were non-stone formers (NF).MethodsSamples for 24-h urine composition were analyzed from 584 NF adults without urolithiasis in a national six-city-based epidemiologic study. The samples were divided into groups based on total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL). The groups were compared based on demographic data and each component of 24-h urinalysis.ResultsThe numbers of participants in high TG, high TC, high LDL, and low HDL were 106, 175, 147, and 59, respectively. The high TG group had increased urinary excretions of oxalate [mean difference (MD)=0.032mmol, 95% confidence interval (CI): 0.000-0.065] and potassium (MD=4.298mmol, 95%CI: 0.182-8.414). Increased urinary excretion of calcium (MD=0.531mmol, 95%CI: 0.061-1.001), sodium (MD=41.561mmol, 95%CI: 9.179-73.942), and chloride (MD=45.209mmol, 95%CI: 12.118-78.299) were found in the high TC group. Interestingly, the high LDL group had a decreased urinary excretion of calcium (MD=-0.573mmol, 95%CI: -1.048 to -0.097), oxalate (MD=-0.038mmol, 95%CI: -0.07 to -0.006), sodium (MD=-53.285mmol, 95%CI: -85.823 to -20.748), and chloride (MD=-55.809mmol, 95%CI: -89.035 to -22.583). Increased urinary excretions of citrate (MD=0.455mmol, 95%CI: 0.076-0.835) and magnesium (MD=0.697mmol, 95%CI: 0.244-1.149) were found in the low HDL group.ConclusionsThe present study first investigated the effects of dyslipidemia on 24-h urinalysis in NF adults. Of note, high LDL and low HDL were found to be adversely related to kidney stone formation. However, people with high TG and high TC should be cautious of getting kidney stones.