Surging bloodstream infections and antimicrobial resistance during the first wave of COVID-19: a study in a large multihospital institution in the Paris region

被引：36

作者：

Amarsy, Rishma ^{[1
,2
]}

Trystram, David ^{[3
,4
]}

Cambau, Emmanuelle ^{[5
,6
]}

Monteil, Catherine ^{[7
]}

Fournier, Sandra ^{[7
]}

Oliary, Juliette ^{[8
]}

Junot, Helga ^{[9
]}

Sabatier, Pierre ^{[10
]}

Porcher, Raphael ^{[11
,12
]}

Robert, Jerome ^{[2
,3
]}

Jarlier, Vincent ^{[2
,3
]}

机构：

[1] Univ Paris, Grp Hosp Univ, AP HP Nord, Site Lariboisiere & Fernand Widal,Infect Prevent, Paris, France

[2] Sorbonne Univ, Inserm U1135, CIMI Paris, Paris, France

[3] Sorbonne Univ, Grp Hosp Univ, AP HP, Site Pitie Salpetriere,Lab Bacteriol Hyg, Paris, France

[4] AP HP, Syst Informat, Paris, France

[5] Univ Paris, Grp Hosp Univ, AP HP Nord, Site Lariboisiere,Lab Microbiol Hyg, Paris, France

[6] Inserm UMR1137 IAME, Paris, France

[7] AP HP, Cent Infect Control Team, Paris, France

[8] Univ Paris, Grp Hosp Univ, AP HP Nord, Site Lariboisiere,Pharm, Paris, France

[9] Sorbonne Univ, Grp Hosp Univ, AP HP, Site Pitie Salpetriere,Pharm, Paris, France

[10] AP HP, Agence Gen Equipements & Prod Sante, Paris, France

[11] Univ Paris, Grp Hosp Univ, AP HP Ctr, Site Hotel Dieu,Ctr Clin Epidemiol, Paris, France

[12] Univ Paris, CRESS, UMR1153, INSERM,INRAE, Paris, France

来源：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2022年 / 114卷

关键词：

COVID-19; Blood culture; Bloodstream infection incidence; Antibiotic consumption; Antimicrobial resistance; INTENSIVE-CARE; IMPACT; SARS;

D O I：

10.1016/j.ijid.2021.10.034

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Objectives: This study measured the impact of the first wave of COVID-19 pandemic (COVID-19) (March-April 2020) on the incidence of bloodstream infections (BSIs) at Assistance Publique - Hopitaux de Paris (APHP), the largest multisite public healthcare institution in France. Methods: The number of patient admission blood cultures (BCs) collected, number of positive BCs, and antibiotic resistance and consumption were analysed retrospectively for the first quarter of 2020, and also for the first quarter of 2019 for comparison, in 25 APHP hospitals (ca. 14 000 beds). Results: Up to a fourth of patients admitted in March-April 2020 in these hospitals had COVID-19. The BSI rate per 100 admissions increased overall by 24% in March 2020 and 115% in April 2020, and separately for the major pathogens (Escherichia coli, Klebsiella pneumoniae, enterococci, Staphylococcus aureus, Pseudomonas aeruginosa, yeasts). A sharp increase in the rate of BSIs caused by microorganisms resistant to third-generation cephalosporins (3GC) was also observed in March-April 2020, particularly in K. pneumoniae, enterobacterial species naturally producing inducible AmpC (Enterobacter cloacae...), and P. aeruginosa. A concomitant increase in 3GC consumption occurred. Conclusions: The COVID-19 pandemic had a strong impact on hospital management and also unfavourable effects on severe infections, antimicrobial resistance, and laboratory work diagnostics. (C) 2021 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.

引用

页码：90 / 96

页数：7

共 35 条

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