Crohn's disease associated with interferon and ribavirin treatment for chronic hepatitis C

被引：19

作者：

Khalil, A

Lucidarme, D

Desurmont, P

Hamdan-Khalil, R

Filoche, B

机构：

[1] Hop St Philibert, Serv Pathol Digest, F-59462 Lomme Les Lille, France

[2] Cabinet Gastroenterol, F-59000 Lille, France

[3] CHRU Lille, Fac Med, EA 2679, F-59045 Lille, France

来源：

GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE | 2005年 / 29卷 / 02期

关键词：

D O I：

10.1016/S0399-8320(05)80736-5

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Digestive side effects associated with interferon and ribavirin in the treatment of chronic hepatitis C seem to be non specific. So for, inflammatory bowel diseases have only been rarely described in this context. We report two cases of Crohn's disease which occurred a few months after interferon and ribavirin treatment for chronic hepatitis C. The first case was a 43 year old man treated for 7 months with a interferon and ribavirin combination for chronic hepatitis C who experienced colitis related to Crohn's disease, with the occurrence of articular and cutaneous manifestations. The second case was a 43 year old women treated for 8 months with a pegylated interferon and ribavirin combination for chronic hepatitis C who developed Crohn's disease with right ileo-colic topography and severe evolution requiring an ileo-coecal resection because of the failure of medical treatment. The alpha interferon used for its antiviral action against hepatitis C virus, has complex immuno-modulation effects which could reveal latent Crohn's disease.

引用

页码：193 / 196

页数：4

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