Still cooling after all these years: Meta-analysis of pre-clinical trials of therapeutic hypothermia for acute ischemic stroke

被引：73

作者：

Dumitrascu, Oana M. ^{[1
]}

Lamb, Jessica ^{[1
]}

Lyden, Patrick D. ^{[1
]}

机构：

[1] Cedars Sinai Med Ctr, Dept Neurol, 127 S San Vicente Blvd,AHSP 6417, Los Angeles, CA 90036 USA

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2016年 / 36卷 / 07期

关键词：

Acute stroke; animal models; hypothermia; neuroprotection; reperfusion; VOLUME;

D O I：

10.1177/0271678X16645112

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Therapeutic hypothermia is the most potent neuroprotectant for experimental cerebral ischemia, illustrated in a 2007 meta-analysis published in this journal. To address recent therapeutic nihilism, we systematically reviewed recent experimental literature. Quality scoring showed considerable improvement in study design. Using several outcome measures in a variety of models and species, therapeutic hypothermia was protective compared with normothermia, with powerful and statistically significant normalized treatment effect sizes, in 60 papers comprising 216 comparisons. In the past 5 years, preclinical studies of ischemic stroke re-emphasize that therapeutic hypothermia is potently effective, justifying further development in larger human clinical trials.

引用

页码：1157 / 1164

页数：8

共 12 条

[1] Endovascular stent thrombectomy: the new standard of care for large vessel ischaemic stroke [J].

Campbell, Bruce C. V. ;

Donnan, Geoffrey A. ;

Lees, Kennedy R. ;

Hacke, Werner ;

Khatri, Pooja ;

Hill, Michael D. ;

Goyal, Mayank ;

Mitchell, Peter J. ;

Saver, Jeffrey L. ;

Diener, Hans-Christoph ;

Davis, Stephen M. .

LANCET NEUROLOGY, 2015, 14 (08) :846-854

[2] Endovascular therapeutic hypothermia for acute ischemic stroke: ICTuS 2/3 protocol [J].

Lyden, Patrick D. ;

Hemmen, Thomas M. ;

Grotta, James ;

Rapp, Karen ;

Raman, Rema .

INTERNATIONAL JOURNAL OF STROKE, 2014, 9 (01) :117-125

[3] Good Laboratory Practice Preventing Introduction of Bias at the Bench [J].

Macleod, Malcolm R. ;

Fisher, Marc ;

O'Collins, Victoria ;

Sena, Emily S. ;

Dirnagl, Ulrich ;

Bath, Philip M. W. ;

Buchan, Alistair ;

van der Worp, H. Bart ;

Traystman, Richard ;

Minematsu, Kazuo ;

Donnan, Geoffrey A. ;

Howells, David W. .

STROKE, 2009, 40 (03) :E50-E52

[4] Catheter based selective hypothermia reduces stroke volume during focal cerebral ischemia in swine [J].

Mattingly, Thomas K. ;

Denning, Lynn M. ;

Siroen, Karen L. ;

Lehrbass, Barb ;

Lopez-Ojeda, Pablo ;

Stitt, Larry ;

Pelz, David M. ;

Das, Sumit ;

Ang, Lee-Cyn ;

Lee, Donald H. ;

Lownie, Stephen P. .

JOURNAL OF NEUROINTERVENTIONAL SURGERY, 2016, 8 (04) :418-422

[5] Targeted Temperature Management at 33°C versus 36°C after Cardiac Arrest [J].

Nielsen, Niklas ;

Wettersley, Jorn ;

Cronberg, Tobias ;

Erlinge, David ;

Gasche, Yvan ;

Hassager, Christian ;

Horn, Janneke ;

Hovdenes, Jan ;

Kjaergaard, Jesper ;

Kuiper, Michael ;

Pellis, Tommaso ;

Stammet, Pascal ;

Wanscher, Michael ;

Wise, Matt P. ;

Aneman, Anders ;

Al-Subaie, Nawaf ;

Boesgaard, Soren ;

Bro-Jeppesen, John ;

Brunetti, Iole ;

Bugge, Jan Frederik ;

Hingston, Christopher D. ;

Juffermans, Nicole P. ;

Koopmans, Matty ;

Kober, Lars ;

Langorgen, Jorund ;

Lilja, Gisela ;

Moller, Jacob Eifer ;

Rundgren, Malin ;

Rylander, Christian ;

Smid, Ondrej ;

Werer, Christophe ;

Winkel, Per ;

Friberg, Hans .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (23) :2197-2206

[6] Delayed Selective Cerebral Hypothermia Decreases Infarct Volume After Reperfused Stroke in Baboons [J].

Schwartz, Arthur E. ;

Finck, A. Donald ;

Stone, J. Gilbert ;

Connolly, E. Sander ;

Edwards, Niloo M. ;

Mongero, Linda .

JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY, 2011, 23 (02) :124-130

[7] Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy [J].

Sena, Emily S. ;

van der Worp, H. Bart ;

Bath, Philip M. W. ;

Howells, David W. ;

Macleod, Malcolm R. .

PLOS BIOLOGY, 2010, 8 (03)

[8] Hypothermia in animal models of acute ischaemic stroke: a systematic review and meta-analysis [J].

van der Worp, H. Bart ;

Sena, Emily S. ;

Donnan, Geoffrey A. ;

Howells, David W. ;

Macleod, Malcolm R. .

BRAIN, 2007, 130 :3063-3074

[9] EuroHYP-1: European multicenter, randomized, phase III clinical trial of therapeutic hypothermia plus best medical treatment vs. best medical treatment alone for acute ischemic stroke [J].

van der Worp, H. Bart ;

Macleod, Malcolm R. ;

Bath, Philip M. W. ;

Demotes, Jacques ;

Durand-Zaleski, Isabelle ;

Gebhardt, Bernd ;

Gluud, Christian ;

Kollmar, Rainer ;

Krieger, Derk W. ;

Lees, Kennedy R. ;

Molina, Carlos ;

Montaner, Joan ;

Roine, Risto O. ;

Petersson, Jesper ;

Staykov, Dimitre ;

Szabo, Istvan ;

Wardlaw, Joanna M. ;

Schwab, Stefan .

INTERNATIONAL JOURNAL OF STROKE, 2014, 9 (05) :642-645

[10] Therapeutic hypothermia for acute ischemic stroke: ready to start large randomized trials? [J].

van der Worp, H. Bart ;

Macleod, Malcolm R. ;

Kollmar, Rainer .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2010, 30 (06) :1079-1093

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