Epigenetics in psoriasis: perspective of DNA methylation

被引：19
作者：
Luo, Ying [1 ,2 ]
Qu, Keshen [3 ]
Kuai, Le [1 ]
Ru, Yi [1 ]
Huang, Keke [1 ]
Yan, Xiaoning [4 ]
Xing, Meng [4 ]
机构：
[1] Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western, Dept Dermatol, Shanghai 200437, Peoples R China
[2] Shanghai Acad Tradit Chinese Med, Inst Dermatol, Shanghai 201203, Peoples R China
[3] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Dept Tradit Chinese Surg, Shanghai 200032, Peoples R China
[4] Shaanxi Hosp Tradit Chinese Med, Dept Dermatol, 4 West Glorious Gate, Xian 710003, Peoples R China
来源：
MOLECULAR GENETICS AND GENOMICS | 2021年 / 296卷 / 05期
关键词：
DNA methylation; Psoriasis; Epigenetic; Sequencing; Research progress; PROTEIN-TYROSINE-PHOSPHATASE; LOOP-HELIX PROTEINS; CELL-PROLIFERATION; SHP-1; EXPRESSION; GENE; RETROTRANSPOSONS; IDENTIFICATION; TRANSCRIPTION; LOCALIZATION;
D O I：
10.1007/s00438-021-01804-y
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Psoriasis is a chronic inflammatory skin disease characterized by excessive proliferation of keratinocytes (KCs). Onset of psoriasis is related to genetic, immune and environmental factors. The environment can interact with the genome through epigenetic modifications, including DNA methylation, and this modification is involved in the pathogenesis of psoriasis. In addition to a skin disease, psoriasis is also considered a systemic disease. We reviewed the current literature of psoriatic DNA methylation for studies from several aspects on the DNA methylation distribution patterns in different tissues/cells, single-nucleotide polymorphisms, and candidate disease genes and identified target genes regulated by DNA methylation that have been directly/indirectly validated. This review contributes to a comprehensive understanding of the important a role that DNA methylation plays in psoriasis from a holistic perspective and will promote the implementation of DNA methylation in diagnostic and therapeutic strategies for psoriatic patients.
引用
收藏
页码：1027 / 1040
页数：14
相关论文
共 73 条
[1]   Human mesenchymal stem cells modulate allogeneic immune cell responses [J].
Aggarwal, S ;
Pittenger, MF .
BLOOD, 2005, 105 (04) :1815-1822
[2]   Trio GEF mediates RhoA activation downstream of Slit2 and coordinates telencephalic wiring [J].
Backer, Stephanie ;
Lokmane, Ludmilla ;
Landragin, Camille ;
Deck, Marie ;
Garel, Sonia ;
Bloch-Gallego, Evelyne .
DEVELOPMENT, 2018, 145 (19)
[3]   S100 protein subcellular localization during epidermal differentiation and psoriasis [J].
Broome, AM ;
Ryan, D ;
Eckert, RL .
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 2003, 51 (05) :675-685
[4]   Role of the tyrosine phosphatase SHP-1 in K562 cell differentiation [J].
Bruecher-Encke, B ;
Griffin, JD ;
Neel, BG ;
Lorenz, U .
LEUKEMIA, 2001, 15 (09) :1424-1432
[5]   Epigenome-wide DNA methylation regulates cardinal pathological features of psoriasis [J].
Chandra, Aditi ;
Senapati, Swapan ;
Roy, Sudipta ;
Chatterjee, Gobinda ;
Chatterjee, Raghunath .
CLINICAL EPIGENETICS, 2018, 10
[6]   C10orf99 contributes to the development of psoriasis by promoting the proliferation of keratinocytes [J].
Chen, Caifeng ;
Wu, Na ;
Duan, Qiqi ;
Yang, Huizi ;
Wang, Xin ;
Yang, Peiwen ;
Zhang, Mengdi ;
Liu, Jiankang ;
Liu, Zhi ;
Shao, Yongping ;
Zheng, Yan .
SCIENTIFIC REPORTS, 2018, 8
[7]   The role of Rho-GEF Trio in regulating tooth root development through the p38 MAPK pathway [J].
Chen, Huimin ;
Guo, Shuyu ;
Xia, Yang ;
Yuan, Lichan ;
Lu, Mengting ;
Zhou, Meng ;
Fang, Mengru ;
Meng, Li ;
Xiao, Zhongdang ;
Ma, Junqing .
EXPERIMENTAL CELL RESEARCH, 2018, 372 (02) :158-167
[8]   The methylation pattern of p16INK4a gene promoter in psoriatic epidermis and its clinical significance [J].
Chen, M. ;
Chen, Z-Q. ;
Cui, P-G. ;
Yao, X. ;
Li, Y-M. ;
Li, A-S. ;
Gong, J-Q. ;
Cao, Y-H. .
BRITISH JOURNAL OF DERMATOLOGY, 2008, 158 (05) :987-993
[9]   Mahogunin ring finger-1 (MGRN1) Suppresses Chaperone-Associated Misfolded Protein Aggregation and Toxicity [J].
Chhangani, Deepak ;
Mishra, Amit .
SCIENTIFIC REPORTS, 2013, 3
[10]   Oligoadenylate synthase-like (OASL) proteins: dual functions and associations with diseases [J].
Choi, Un Yung ;
Kang, Ji-Seon ;
Hwang, Yune Sahng ;
Kim, Young-Joon .
EXPERIMENTAL AND MOLECULAR MEDICINE, 2015, 47 :e144-e144
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