Phototherapy and multimodal imaging of cancers based on perfluorocarbon nanomaterials

被引：16

作者：

Han, Zhaoguo ^{[1
,2
,3
]}

Tu, Xianshuang ^{[2
]}

Qiao, Lina ^{[1
,3
]}

Sun, Yige ^{[1
,3
]}

Li, Zibo ^{[2
]}

Sun, Xilin ^{[1
,3
]}

Wu, Zhanhong ^{[2
]}

机构：

[1] Harbin Med Univ, Mol Imaging Res Ctr MIRC, NHC & CAMS Key Lab Mol Probe & Targeted Theranost, Harbin, Peoples R China

[2] Univ North Carolina, Biomed Res Imaging Ctr, Dept Radiol, Chapel Hill, NC 27599 USA

[3] Harbin Med Univ, Hosp 4, Dept Nucl Med, Harbin, Peoples R China

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2021年 / 9卷 / 34期

关键词：

ENHANCED PHOTODYNAMIC THERAPY; RESONANCE ENERGY-TRANSFER; TUMORS IN-VIVO; 5-AMINOLEVULINIC ACID; POLYETHYLENE-GLYCOL; HYPERBARIC-OXYGEN; NANOPARTICLE SIZE; HYPOXIA RELIEF; DRUG-DELIVERY; ULTRASOUND;

D O I：

10.1039/d1tb00554e

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Phototherapy, such as photodynamic therapy (PDT) and photothermal therapy (PTT), possesses unique characteristics of non-invasiveness and minimal side effects in cancer treatment, compared with conventional therapies. However, the ubiquitous tumor hypoxia microenvironments could severely reduce the efficacy of oxygen-consuming phototherapies. Perfluorocarbon (PFC) nanomaterials have shown great practical value in carrying and transporting oxygen, which makes them promising agents to overcome tumor hypoxia and extend reactive oxygen species (ROS) lifetime to improve the efficacy of phototherapy. In this review, we summarize the latest advances in PFC-based PDT and PTT, and combined multimodal imaging technologies in various cancer types, aiming to facilitate their application-oriented clinical translation in the future.

引用

页码：6751 / 6769

页数：19

共 137 条

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