Gated Mesoporous Silica Nanoparticles Using a Double-Role Circular Peptide for the Controlled and Target-Preferential Release of Doxorubicin in CXCR4-Expresing Lymphoma Cells

被引：51

作者：

de la Torre, Cristina ^{[1
,2
]}

Casanova, Isolda ^{[3
,4
]}

Acosta, Gerardo ^{[5
]}

Coll, Carmen ^{[1
,2
]}

Jose Moreno, Maria ^{[3
,4
]}

Albericio, Fernando ^{[5
,7
,8
]}

Aznar, Elena ^{[1
,2
]}

Mangues, Ramon ^{[3
,4
]}

Royo, Miriam ^{[6
,9
]}

Sancenon, Felix ^{[1
,2
]}

Martinez-Manez, Ramon ^{[1
,2
]}

机构：

[1] Univ Valencia, Unidad Mixta Univ Politecn Valencia, Ctr Reconocimiento Mol & Desarrollo Tecnol IDM, Valencia 46022, Spain

[2] CIBER Bioingn Biomat & Nanomed CIBER BBN, Valencia 46022, Spain

[3] Hosp Santa Creu & Sant Pau, Inst Invest Biomed St Pau, Grp Oncogenesi & Antitumorals, Barcelona 08025, Spain

[4] CIBER Bioingn Biomat & Nanomed, Barcelona 08025, Spain

[5] Univ Barcelona, Inst Res Biomed, Barcelona Sci Pk, E-08028 Barcelona, Spain

[6] CIBER Bioingn Biomat & Nanomed CIBER BBN, Barcelona 08028, Spain

[7] Univ Barcelona, Dept Organ Chem, E-08028 Barcelona, Spain

[8] Yachay City Knowledge, Sch Chem Yachay Tech, Urcuqui, Ecuador

[9] Barcelona Sci Pk, Combinatorial Chem Unit, Barcelona 08028, Spain

来源：

ADVANCED FUNCTIONAL MATERIALS | 2015年 / 25卷 / 05期

关键词：

CXCR4; receptors; gated materials; lymphoma; mesoporous materials; targeting molecules; RESPONSIVE CONTROLLED-RELEASE; CHRONIC LYMPHOCYTIC-LEUKEMIA; DRUG-DELIVERY; CXCR4; ANTAGONIST; GUEST MOLECULES; SYSTEM; DESIGN; MICROENVIRONMENT; CHEMOTHERAPY; NANOCARRIER;

D O I：

10.1002/adfm.201403822

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

B-cell non-Hodgkin's lymphoma (B-NHL) is the most frequent malignant lymphoid neoplasm, which has a high degree of relapse and chemoresistance. Thus, strategies to improve currently used therapies are needed. In this context, a new CXCR4-targeted delivery system is described using mesoporous silica nanoparticles (MSNs) that are loaded with doxorubicin and capped with a derivative of the T22 peptide (P). This design makes full use of the great affinity of the T22 peptide to CXCR4 receptor, which is overexpressed in lymphoma cells. The peptide is able to guide the gated nanoparticle to B-NHL cells to facilitate MSNs uptake via the CXCR4 receptor. The endocyted P-capped MSNs are also opened by endosomal proteolytic enzymes to allow intracellular doxorubicin delivery.

引用

页码：687 / 695

页数：9

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