Coordinating Radiometals of Copper, Gallium, Indium, Yttrium, and Zirconium for PET and SPECT Imaging of Disease

被引：759

作者：

Wadas, Thaddeus J. ^{[1
]}

Wong, Edward H. ^{[2
]}

Weisman, Gary R. ^{[2
]}

Anderson, Carolyn J. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Mallinckrodt Inst Radiol, St Louis, MO 63110 USA

[2] Univ New Hampshire, Dept Chem, Durham, NH 03824 USA

来源：

CHEMICAL REVIEWS | 2010年 / 110卷 / 05期

关键词：

POSITRON-EMISSION-TOMOGRAPHY; EPIDERMAL-GROWTH-FACTOR; HUMAN BREAST-CANCER; IN-VIVO EVALUATION; SECONDARY LIVER MALIGNANCIES; ART BRACHYTHERAPY TREATMENT; STIMULATING HORMONE ANALOG; RECEPTOR-POSITIVE TUMORS; CROSS-BRIDGED CYCLAM; METAL-ION COMPLEXES;

D O I：

10.1021/cr900325h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Researchers have the ability to match the physical characteristics of a specific radio metal with the biokinetics of a particular biological targeting molecule leading to the development of diagnostic and therapeutic radiopharmaceuticals that can be tailored to individual disease processes. Single-photon emission computed tomography (SPECT) requires the use of a contrast agent labeled with a ?-emitting radionuclide, which should have ideal y energy of 100-250 keV. While +1 and +3 oxidation states are both accessible for copper in the presence of suitable donors, 3d9 Cu(II) remains the predominant state for radio copper chemistry in protic media. Radiocopper chelate stability is paramount when developing tumor targeting radiopharmaceuticals so that optimum image quality can be achieved. Perfusion and hypoxia imaging have developed into robust research areas since they allow scientists and clinicians to monitor changes in blood flow and image changes in oxygen demand.

引用

页码：2858 / 2902

页数：45

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