Characterization of Immune Response Diversity in Rodents Vaccinated with a Vesicular Stomatitis Virus Vectored COVID-19 Vaccine

被引:13
作者
Wang, Shen [1 ]
Zhang, Cheng [1 ,2 ]
Liang, Bo [1 ]
Wang, Weiqi [1 ,3 ]
Feng, Na [1 ]
Zhao, Yongkun [1 ]
Wang, Tiecheng [1 ]
Guo, Zhendong [1 ]
Yan, Feihu [1 ]
Yang, Songtao [1 ]
Xia, Xianzhu [1 ]
机构
[1] Chinese Acad Agr Sci, Changchun Vet Res Inst, Key Lab Jilin Prov Zoonosis Prevent & Control, Changchun 130122, Peoples R China
[2] Hebei Agr Univ, Coll Vet Med, Baoding 071000, Peoples R China
[3] Jilin Univ, Coll Vet Med, Changchun 130028, Peoples R China
来源
VIRUSES-BASEL | 2022年 / 14卷 / 06期
关键词
COVID-19; recombinant vesicular stomatitis virus; immunization routes; neutralizing antibody; challenge; rodent; animal models; SINGLE INTRANASAL; PROTECTS; ANTIBODY;
D O I
10.3390/v14061127
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as the prime challenge facing public health safety since 2019. Correspondingly, coronavirus disease 2019 (COVID-19) vaccines have been developed and administered worldwide, varying in design strategies, delivery routes, immunogenicity and protective efficacy. Here, a replication-competent vesicular stomatitis virus (VSV) vectored recombinant COVID-19 vaccine was constructed and evaluated in BALB/c mice and Syrian golden hamsters. In BALB/c mice, intramuscular (i.m.) inoculation of recombinant vaccine induced significantly higher humoral immune response than that of the intranasal (i.n.) inoculation group. Analyses of cellular immunity revealed that a Th1-biased cellular immune response was induced in i.n. inoculation group while both Th1 and Th2 T cells were activated in i.m. inoculation group. In golden hamsters, i.n. inoculation of the recombinant vaccine triggered robust humoral immune response and conferred prominent protective efficacy post-SARS-CoV-2 challenge, indicating a better protective immunity in the i.n. inoculation group than that of the i.m. inoculation group. This study provides an effective i.n.-delivered recombinant COVID-19 vaccine candidate and elucidates a route-dependent manner of this vaccine candidate in two most frequently applied small animal models. Moreover, the golden hamster is presented as an economical and convenient small animal model that precisely reflects the immune response and protective efficacy induced by replication-competent COVID-19 vaccine candidates in other SARS-CoV-2 susceptible animals and human beings, especially in the exploration of i.n. immunization.
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页数:14
相关论文
共 46 条
[1]   Effect of 2 Inactivated SARS-CoV-2 Vaccines on Symptomatic COVID-19 Infection in Adults A Randomized Clinical Trial [J].
Al Kaabi, Nawal ;
Zhang, Yuntao ;
Xia, Shengli ;
Yang, Yunkai ;
Al Qahtani, Manaf M. ;
Abdulrazzaq, Najiba ;
Al Nusair, Majed ;
Hassany, Mohamed ;
Jawad, Jaleela S. ;
Abdalla, Jehad ;
Hussein, Salah Eldin ;
Al Mazrouei, Shamma K. ;
Al Karam, Maysoon ;
Li, Xinguo ;
Yang, Xuqin ;
Wang, Wei ;
Lai, Bonan ;
Chen, Wei ;
Huang, Shihe ;
Wang, Qian ;
Yang, Tian ;
Liu, Yang ;
Ma, Rui ;
Hussain, Zaidoon M. ;
Khan, Tehmina ;
Saifuddin Fasihuddin, Mohammed ;
You, Wangyang ;
Xie, Zhiqiang ;
Zhao, Yuxiu ;
Jiang, Zhiwei ;
Zhao, Guoqing ;
Zhang, Yanbo ;
Mahmoud, Sally ;
ElTantawy, Islam ;
Xiao, Peng ;
Koshy, Ashish ;
Zaher, Walid Abbas ;
Wang, Hui ;
Duan, Kai ;
Pan, An ;
Yang, Xiaoming .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2021, 326 (01) :35-45
[2]  
[Anonymous], WHO CORONAVIRUS COVI
[3]  
[Anonymous], Informacionnyj i statisticheskij otchety
[4]   Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine [J].
Baden, Lindsey R. ;
El Sahly, Hana M. ;
Essink, Brandon ;
Kotloff, Karen ;
Frey, Sharon ;
Novak, Rick ;
Diemert, David ;
Spector, Stephen A. ;
Rouphael, Nadine ;
Creech, C. Buddy ;
McGettigan, John ;
Khetan, Shishir ;
Segall, Nathan ;
Solis, Joel ;
Brosz, Adam ;
Fierro, Carlos ;
Schwartz, Howard ;
Neuzil, Kathleen ;
Corey, Larry ;
Gilbert, Peter ;
Janes, Holly ;
Follmann, Dean ;
Marovich, Mary ;
Mascola, John ;
Polakowski, Laura ;
Ledgerwood, Julie ;
Graham, Barney S. ;
Bennett, Hamilton ;
Pajon, Rolando ;
Knightly, Conor ;
Leav, Brett ;
Deng, Weiping ;
Zhou, Honghong ;
Han, Shu ;
Ivarsson, Melanie ;
Miller, Jacqueline ;
Zaks, Tal .
NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (05) :403-416
[5]   THE TRANSCRIPTION COMPLEX OF VESICULAR STOMATITIS-VIRUS [J].
BANERJEE, AK .
CELL, 1987, 48 (03) :363-364
[6]   The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice [J].
Bao, Linlin ;
Deng, Wei ;
Huang, Baoying ;
Gao, Hong ;
Liu, Jiangning ;
Ren, Lili ;
Wei, Qiang ;
Yu, Pin ;
Xu, Yanfeng ;
Qi, Feifei ;
Qu, Yajin ;
Li, Fengdi ;
Lv, Qi ;
Wang, Wenling ;
Xue, Jing ;
Gong, Shuran ;
Liu, Mingya ;
Wang, Guanpeng ;
Wang, Shunyi ;
Song, Zhiqi ;
Zhao, Linna ;
Liu, Peipei ;
Zhao, Li ;
Ye, Fei ;
Wang, Huijuan ;
Zhou, Weimin ;
Zhu, Na ;
Zhen, Wei ;
Yu, Haisheng ;
Zhang, Xiaojuan ;
Guo, Li ;
Chen, Lan ;
Wang, Conghui ;
Wang, Ying ;
Wang, Xinming ;
Xiao, Yan ;
Sun, Qiangming ;
Liu, Hongqi ;
Zhu, Fanli ;
Ma, Chunxia ;
Yan, Lingmei ;
Yang, Mengli ;
Han, Jun ;
Xu, Wenbo ;
Tan, Wenjie ;
Peng, Xiaozhong ;
Jin, Qi ;
Wu, Guizhen ;
Qin, Chuan .
NATURE, 2020, 583 (7818) :830-+
[7]   STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters [J].
Boudewijns, Robbert ;
Thibaut, Hendrik Jan ;
Kaptein, Suzanne J. F. ;
Li, Rong ;
Vergote, Valentijn ;
Seldeslachts, Laura ;
Van Weyenbergh, Johan ;
De Keyzer, Carolien ;
Bervoets, Lindsey ;
Sharma, Sapna ;
Liesenborghs, Laurens ;
Ma, Ji ;
Jansen, Sander ;
Van Looveren, Dominique ;
Vercruysse, Thomas ;
Wang, Xinyu ;
Jochmans, Dirk ;
Martens, Erik ;
Roose, Kenny ;
De Vlieger, Dorien ;
Schepens, Bert ;
Van Buyten, Tina ;
Jacobs, Sofie ;
Liu, Yanan ;
Marti-Carreras, Joan ;
Vanmechelen, Bert ;
Wawina-Bokalanga, Tony ;
Delang, Leen ;
Rocha-Pereira, Joana ;
Coelmont, Lotte ;
Chiu, Winston ;
Leyssen, Pieter ;
Heylen, Elisabeth ;
Schols, Dominique ;
Wang, Lanjiao ;
Close, Lila ;
Matthijnssens, Jelle ;
Van Ranst, Marc ;
Compernolle, Veerle ;
SchrammH, Georg ;
Van Laere, Koen ;
Saelens, Xavier ;
Callewaert, Nico ;
Opdenakker, Ghislain ;
Maes, Piet ;
Weynand, Birgit ;
Cawthorne, Christopher ;
Vande Velde, Greetje ;
Wang, Zhongde ;
Neyts, Johan .
NATURE COMMUNICATIONS, 2020, 11 (01)
[8]  
Bricker Traci L, 2020, bioRxiv, DOI [10.1016/j.celrep.2021.109400, 10.1101/2020.12.02.408823]
[9]   Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2 [J].
Case, James Brett ;
Rothlauf, Paul W. ;
Chen, Rita E. ;
Liu, Zhuoming ;
Zhao, Haiyan ;
Kim, Arthur S. ;
Bloyet, Louis-Marie ;
Zeng, Qiru ;
Tahan, Stephen ;
Droit, Lindsay ;
Ilagan, Ma Xenia G. ;
Tartell, Michael A. ;
Amarasinghe, Gaya ;
Henderson, Jeffrey P. ;
Miersch, Shane ;
Ustav, Mart ;
Sidhu, Sachdev ;
Virgin, Herbert W. ;
Wang, David ;
Ding, Siyuan ;
Corti, Davide ;
Theel, Elitza S. ;
Fremont, Daved H. ;
Diamond, Michael S. ;
Whelan, Sean P. J. .
CELL HOST & MICROBE, 2020, 28 (03) :475-+
[10]   Replication-Competent Vesicular Stomatitis Virus Vaccine Vector Protects against SARS-CoV-2-Mediated Pathogenesis in Mice [J].
Case, James Brett ;
Rothlauf, Paul W. ;
Chen, Rita E. ;
Kafai, Natasha M. ;
Fox, Julie M. ;
Smith, Brittany K. ;
Shrihari, Swathi ;
McCune, Broc T. ;
Harvey, Ian B. ;
Keeler, Shamus P. ;
Bloyet, Louis-Marie ;
Zhao, Haiyan ;
Ma, Meisheng ;
Adams, Lucas J. ;
Winkler, Emma S. ;
Holtzman, Michael J. ;
Fremont, Daved H. ;
Whelan, Sean P. J. ;
Diamond, Michael S. .
CELL HOST & MICROBE, 2020, 28 (03) :465-+