Bacteriologic features and antimicrobial susceptibility in isolates from orofacial odontogenic infections

被引:135
作者
Kuriyama, T
Karasawa, T
Nakagawa, K
Saiki, Y
Yamamoto, E
Nakamura, S
机构
[1] Kanazawa Univ, Sch Med, Dept Oral & Maxillofacial Surg, Kanazawa, Ishikawa 9208640, Japan
[2] Kanazawa Univ, Sch Med, Dept Bacteriol, Kanazawa, Ishikawa 9208640, Japan
来源
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY | 2000年 / 90卷 / 05期
关键词
D O I
10.1067/moe.2000.109639
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Objective. The aim of this study was to obtain information for an effective antimicrobial therapy against orofacial odontogenic infections; such information was obtained from recent bacteriologic features and antimicrobial susceptibility data. Study design. The bacteriology and antimicrobial susceptibility of major pathogens in 163 patients with orofacial odontogenic infections to 7 antibiotics was examined. Results. Mixed infection of strict anaerobes with facultative anaerobes (especially viridans streptococci) was observed most often in dentoalveolar infections, periodontitis, and pericoronitis. Penicillin (penicillin G) was effective against almost all pathogens, although it did not work well against beta -lactamase-positive Prevotella. Cefmetazole was Effective against all test pathogens. Erythromycin was ineffective against viridans streptococci and most Fusobacterium. Clindamycin exerted a strong antimicrobial activity on anaerobes. Minocycline was effective against almost all the test pathogens. The antimicrobial activity of levofloxacin against viridans streptococci was not strong. Conclusions. An antibiotic that carries out antimicrobial activity against both viridans streptococci and oral anaerobes should be suitable for treatment of dentoalveolar infection, periodontitis, and pericoronitis. Penicillin remains effective as an antimicrobial against most major pathogens in orofacial odontogenic infections. Cefmetazole clindamycin, and minocycline may be effective against most pathogens, including penicillin-unsusceptible bacteria.
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页码:600 / 608
页数:9
相关论文
共 32 条
[1]   AMPICILLIN CONCENTRATIONS IN HUMAN-SERUM, GINGIVA, THE MANDIBULAR BONE, AND DENTAL FOLLICLE FOLLOWING A SINGLE ORAL-ADMINISTRATION [J].
AKIMOTO, Y ;
NISHIMURA, H ;
KOMIYA, M ;
SHIBATA, T ;
KANEKO, K ;
FUJII, A ;
TAMURA, T .
GENERAL PHARMACOLOGY, 1985, 16 (02) :125-128
[2]   BETA-LACTAMASE PRODUCTION AND SUSCEPTIBILITIES TO AMOXICILLIN, AMOXICILLIN-CLAVULANATE, TICARCILLIN, TICARCILLIN-CLAVULANATE, CEFOXITIN, IMIPENEM, AND METRONIDAZOLE OF 320 NON-BACTEROIDES-FRAGILIS-BACTEROIDES ISOLATES AND 129 FUSOBACTERIA FROM 28 UNITED-STATES CENTERS [J].
APPELBAUM, PC ;
SPANGLER, SK ;
JACOBS, MR .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1990, 34 (08) :1546-1550
[3]  
Baker K A, 1994, Dent Clin North Am, V38, P689
[4]   AEROBIC AND ANAEROBIC MICROBIOLOGY OF PERIAPICAL ABSCESS [J].
BROOK, I ;
FRAZIER, EH ;
GHER, ME .
ORAL MICROBIOLOGY AND IMMUNOLOGY, 1991, 6 (02) :123-125
[5]   CONCENTRATIONS OF AZIDOCILLIN, ERYTHROMYCIN, DOXYCYCLINE AND CLINDAMYCIN IN HUMAN MANDIBULAR BONE [J].
BYSTEDT, H ;
DAHLBACK, A ;
DORNBUSCH, K ;
NORD, CE .
INTERNATIONAL JOURNAL OF ORAL SURGERY, 1978, 7 (05) :442-449
[6]   Present status of therapy for anaerobic infections [J].
Finegold, SM ;
Wexler, HM .
CLINICAL INFECTIOUS DISEASES, 1996, 23 :S9-S14
[7]   Recently described clinically important anaerobic bacteria: Medical aspects [J].
Finegold, SM ;
JousimiesSomer, H .
CLINICAL INFECTIOUS DISEASES, 1997, 25 :S88-S93
[8]   THE DEVELOPMENT OF PENICILLIN-RESISTANT ORAL STREPTOCOCCI AFTER REPEATED PENICILLIN PROPHYLAXIS [J].
FLEMING, P ;
FEIGAL, RJ ;
KAPLAN, EL ;
LILJEMARK, WF ;
LITTLE, JW .
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS, 1990, 70 (04) :440-444
[9]   POTENTIATION OF OPSONIZATION AND PHAGOCYTOSIS OF STREPTOCOCCUS-PYOGENES FOLLOWING GROWTH IN THE PRESENCE OF CLINDAMYCIN [J].
GEMMELL, CG ;
PETERSON, PK ;
SCHMELING, D ;
KIM, Y ;
MATHEWS, J ;
WANNAMAKER, L ;
QUIE, PG .
JOURNAL OF CLINICAL INVESTIGATION, 1981, 67 (05) :1249-1256
[10]   OROFACIAL ODONTOGENIC INFECTIONS - REVIEW OF MICROBIOLOGY AND CURRENT TREATMENT [J].
GILL, Y ;
SCULLY, C .
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY, 1990, 70 (02) :155-158