A first comparative map of copy number variations in the sheep genome

被引：93

作者：

Fontanesi, L. ^{[1
]}

Beretti, F. ^{[1
,2
]}

Martelli, P. L. ^{[3
]}

Colombo, M. ^{[1
]}

Dall'Olio, S. ^{[1
]}

Occidente, M. ^{[4
]}

Portolano, B. ^{[2
]}

Casadio, R. ^{[3
]}

Matassino, D. ^{[4
]}

Russo, V. ^{[1
]}

机构：

[1] Univ Bologna, DIPROVAL, Sez Allevamenti Zootecn, I-42123 Reggio Emilia, Italy

[2] Univ Palermo, Sez Prod Anim, Dept SEnFiMiZo, I-90128 Palermo, Italy

[3] Univ Bologna, Dept Expt & Evolutionary Biol, Biocomp Grp, I-40126 Bologna, Italy

[4] ConSDABI Italian Sub Natl Focal Point FAO AnGR Me, I-82100 Benevento, Italy

来源：

GENOMICS | 2011年 / 97卷 / 03期

关键词：

aCGH; Comparative map; Copy number variation; Ovis aries; Ruminants; Sheep breeds; MAJOR HISTOCOMPATIBILITY COMPLEX; SIGNALING PROTEIN ASIP; RADIATION HYBRID PANEL; GENE-EXPRESSION; LINKAGE MAP; STRUCTURAL VARIATION; COAT COLORS; EVOLUTION; DIVERSITY; SEQUENCE;

D O I：

10.1016/j.ygeno.2010.11.005

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We carried out a cross species cattle-sheep array comparative genome hybridization experiment to identify copy number variations (CNVs) in the sheep genome analysing ewes of Italian dairy or dual-purpose breeds (Bagnolese, Comisana, Laticauda, Massese, Sarda, and Valle del Belice) using a tiling oligonucleotide array with similar to 385,000 probes designed on the bovine genome. We identified 135 CNV regions (CNVRs; 24 reported in more than one animal) covering similar to 10.5 Mb of the virtual sheep genome referred to the bovine genome (0.398%) with a mean and a median equal to 77.6 and 55.9 kb, respectively. A comparative analysis between the identified sheep CNVRs and those reported in cattle and goat genomes indicated that overlaps between sheep and both other species CNVRs are highly significant (P<0.0001), suggesting that several chromosome regions might contain recurrent interspecies CNVRs. Many sheep CNVRs include genes with important biological functions. Further studies are needed to evaluate their functional relevance. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：158 / 165

页数：8

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