Developmental and epileptic encephalopathies: Is prognosis related to different epileptic network dysfunctions?

被引：10

作者：

Lin, Jainn-Jim ^{[1
,2
,3
,4
]}

Meletti, Stefano ^{[7
,8
]}

Vaudano, Anna Elisabetta ^{[5
,8
]}

Lin, Kuang-Lin ^{[6
]}

机构：

[1] Chang Gung Univ, Div Pediat Crit Care & Pediat Neurocrit Care Ctr, Coll Med, Chang Gung Childrens Hosp, Taoyuan, Taiwan

[2] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Taoyuan, Taiwan

[3] Chang Gung Univ, Coll Med, Grad Inst, Clin Med Sci, Taoyuan, Taiwan

[4] Chang Gung Univ, Coll Med, Div Pediat Neurol, Chang Gung Childrens Hosp, Taoyuan, Taiwan

[5] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Taoyuan, Taiwan

[6] Chang Gung Childrens Hosp, Study Grp Intens & Integrated Care Pediat Cent Ne, Taoyuan, Taiwan

[7] Univ Hosp Modena, Div Neurol, Modena, Italy

[8] Univ Modena & Reggio Emilia, Dept Biomed Metab & Neural Sci, Modena, Italy

来源：

EPILEPSY & BEHAVIOR | 2022年 / 131卷

关键词：

Developmental and epileptic encephalopathies; Prognosis; Epileptic network dysfunction; Genetic mutation; EEG-FMRI; NEURONAL NETWORKS; ILAE COMMISSION; SLEEP; PATHOPHYSIOLOGY; CLASSIFICATION; CONNECTIVITY; MUTATIONS; SPECTRUM; SPIKES;

D O I：

10.1016/j.yebeh.2020.107654

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Developmental and epileptic encephalopathies are a group of rare, severe epilepsies, which are characterized by refractory seizures starting in infancy or childhood and developmental delay or regression. Developmental changes might be independent of epilepsy. However, interictal epileptic activity and seizures can further deteriorate cognition and behavior. Recently, the concept of developmental and epileptic encephalopathies has moved from the lesions associated with epileptic encephalopathies toward the epileptic network dysfunctions on the functioning of the brain. Early recognition and differentiation of patients with developmental and epileptic encephalopathies is important, as precision therapies need to be holistic to address the often devastating symptoms. In this review, we discuss the evolution of the concept of developmental and epileptic encephalopathies in recent years, as well as the current understanding of the genetic basis of developmental and epileptic encephalopathies. Finally, we will discuss the role of epileptic network dysfunctions on prognosis for these severe conditions. (C) 2020 Elsevier Inc. All rights reserved.

引用

页数：5

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