Regiospecific synthesis of 2,3-disubstituted-L-histidines and histamines

被引：33

作者：

Narayanan, S ^{[1
]}

Vangapandu, S ^{[1
]}

Jain, R ^{[1
]}

机构：

[1] Natl Inst Pharmaceut Educ & Res, Dept Med Chem, SAS Nagar 160062, Punjab, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(01)00154-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Regiospecific synthesis of 2,3-disubstituted-L-histidines and 2,3-disubstituted histamines starting from L-histidine methyl ester and histamine is reported, The key step involves homolytic free radical alkylation via silver catalyzed oxidative decarboxylation of alkylcarboxylic acids with ammonium persulfate. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1133 / 1136

页数：4

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