One new lignan and one new fluorenone from Dendrobium nobile Lindl

被引：12

作者：

Cao, Xue ^{[1
,2
,3
]}

Yang, Li ^{[1
,2
]}

Dai, Hao-Fu ^{[1
,2
]}

Wei, Yan-Mei ^{[1
,2
]}

Huang, Sheng-Zhuo ^{[1
,2
]}

Wang, Hao ^{[1
,2
]}

Cai, Cai-Hong ^{[1
,2
]}

Wang, Ling ^{[3
]}

Mei, Wen-Li ^{[1
,2
]}

Chen, Hui-Qin ^{[1
,2
]}

机构：

[1] Chinese Acad Trop Agr Sci, Hainan Key Lab Res & Dev Nat Prod Li Folk Med, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China

[2] Chinese Acad Trop Agr Sci, Hainan Inst Trop Agr Resources, Haikou 571101, Peoples R China

[3] Heinrich Heine Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, Univ Str 1, D-40225 Dusseldorf, Germany

来源：

PHYTOCHEMISTRY LETTERS | 2021年 / 44卷

关键词：

Dendrobium nobile Lindl; alpha-Glucosidase; Lignan; Fluorenone; BIBENZYL DERIVATIVES; SESQUITERPENOIDS; STEMS; ASSAY;

D O I：

10.1016/j.phytol.2021.06.022

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new compounds, dendronobilate (1) and 4-O-demethyl-nobilone (2), together with one known fluorenone were isolated from the aerial parts of Dendrobium nobile Lindl. Their structures were characterized by detailed analysis of 1D and 2D NMR spectra, HRESIMS and ECD spectra. Compounds 1-3 showed significant alpha-glucosidase inhibitory activity with IC50 values of 27.46 +/- 3.14, 4.52 +/- 0.33, and 10.78 +/- 2.05 mu M, respectively, which were superior to the acarbose (745.9 +/- 3.3 mu M). The binding interactions of 1 and 2 with alpha-glucosidase were investigated using molecular docking simulations. In addition, compound 2 exhibited potent inhibitory effect on NO production in LPS activated RAW264.7 cells with the IC50 value of 35.40 +/- 1.77 mu M without cytotoxicity observed.

引用

页码：164 / 168

页数：5

共 23 条

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