New caffeoyl derivatives from Elephantopus scaber

被引：1

作者：

Fu, Lu ^{[1
]}

Pei, Di ^{[1
]}

Yu, Meng ^{[1
]}

Li, Ling-Yu ^{[1
]}

Jia, Hong-Mei ^{[1
]}

Zhang, Hong-Wu ^{[1
]}

Shang, Hai ^{[1
]}

Yu, Shi-Shan ^{[2
]}

Zhang, Tao ^{[1
]}

Zou, Zhong-Mei ^{[1
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Beijing 100193, Peoples R China

[2] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, Beijing 100150, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2022年 / 24卷 / 08期

关键词：

Anti-inflammatory; Asteraceae; caffeoyl derivatives; Elephantopus scaber; CHEMICAL-CONSTITUENTS; L;

D O I：

10.1080/10286020.2021.1974005

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new caffeoyl derivatives (1-3), together with two known ones (4-5), were isolated from the whole plant of Elephantopus scaber Linn. The structures of the new compounds were elucidated using detailed spectroscopic analysis. Compound 4 was obtained and its NMR data were given for the first time. All isolates were evaluated for their anti-inflammatory activity against lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production and pro-inflammatory cytokines release in RAW 264.7 cells. Compounds 2-5 showed mild inhibitory activities with IC50 values ranging from 64.78 to 87.21 mu M, and 3-4 could inhibit LPS-induced tumor necrosis factor-alpha (TNF-alpha) production.

引用

页码：713 / 721

页数：9

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