Amygdala NRG1-ErbB4 Is Critical for the Modulation of Anxiety-Like Behaviors

被引：67

作者：

Bi, Lin-Lin ^{[1
,2
,3
]}

Sun, Xiang-Dong ^{[1
,2
,4
]}

Zhang, Jie ^{[1
,2
]}

Lu, Yi-Sheng ^{[4
]}

Chen, Yi-Hua ^{[1
,2
]}

Wang, Jue ^{[1
,2
]}

Geng, Fei ^{[1
,2
]}

Liu, Fang ^{[4
]}

Zhang, Meng ^{[1
,2
]}

Liu, Ji-Hong ^{[1
,2
]}

Li, Xiao-Wen ^{[1
,2
]}

Mei, Lin ^{[1
,2
,4
]}

Gao, Tian-Ming ^{[1
,2
]}

机构：

[1] Southern Med Univ, Sch Basic Med Sci, Dept Neurobiol, State Key Lab Organ Failure Res, Guangzhou, Guangdong, Peoples R China

[2] Southern Med Univ, Key Lab Psychiatnc Disorders Guangdong Prov, Guangzhou, Guangdong, Peoples R China

[3] Huazhong Univ Sci & Technol, Inst Brain Res, Wuhan 430074, Peoples R China

[4] Georgia Regents Univ, Med Coll Georgia, Dept Neurosci & Regenerat Med, Augusta, GA 30912 USA

来源：

NEUROPSYCHOPHARMACOLOGY | 2015年 / 40卷 / 04期

基金：

中国国家自然科学基金;

关键词：

NEUREGULIN; 1; REGULATION; PLUS-MAZE TEST; SYNAPTIC PLASTICITY; GABAERGIC INTERNEURONS; BASOLATERAL AMYGDALA; FEAR EXTINCTION; RAT; ERBB4; PARVALBUMIN; GABA;

D O I：

10.1038/npp.2014.274

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Anxiety disorder is related to the pathophysiology of psychiatric diseases, including major depression, substance abuse, and schizophrenia. The amygdala is important for manifestation and modulation of anxiety. However, relatively little is known regarding the mechanisms that control the amygdala inhibitory activity that is involved in anxiety. We found that almost all ErbB4, which is the only autonomous receptor of neuregulin 1 (NRG1) in the basolateral amygdala (BLA), was expressed in GABAergic neurons. Endogenous NRG1 ErbB4 signaling pathway in the BLA could modulate anxiety-like behaviors and GABA release, whereas it had no effect on glutamatergic transmission. The administration of NRG1 into the BLA of high-anxiety mice alleviated their anxiety and enhanced GABAergic neurotransmission. Moreover, exogenous NRG1 also produced an anxiolytic effect in the stressed mice. Together, these observations indicated that NRG1 ErbB4 signaling is critical to maintaining GABAergic activity in the amygdala and thus to modulating anxiety-like behaviors. Because NRG1 and ErbB4 are susceptibility genes of schizophrenia, our findings might also help to explain the potential mechanism of emotional abnormality in schizophrenia.

引用

页码：974 / 986

页数：13

共 51 条

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