Electrospray ionization mass spectrometry of cyclodextrin complexes of amino acids and peptides

被引：19
|
作者：
Prokai, L [1 ]
Ramanathan, R [1 ]
Nawrocki, J [1 ]
Eyler, J [1 ]
机构：
[1] UNIV FLORIDA,DEPT CHEM,GAINESVILLE,FL 32611
来源：
JOURNAL OF INCLUSION PHENOMENA AND MOLECULAR RECOGNITION IN CHEMISTRY | 1996年 / 25卷 / 1-3期
关键词：
D O I：
10.1007/BF01041549
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Appropriate complex-forming side-chains of peptides and proteins can bind cyclodextrins. We have characterized interactions of amino acids with cyclodextrins by electrospray ionization mass spectrometry. The stoichiometry of various alpha-cyclodextrin/protonated tryptophan complexes sampled from solution to the gas phase by ESI was revealed by taking advantage of the extended mass range and high mass resolution of a Fourier-transform ion cyclotron resonance instrument. Binding of beta-cyclodextrin to recombinant human insulin has been demonstrated.
引用
收藏
页码：117 / 120
页数：4
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