HTRA proteases: regulated proteolysis in protein quality control

被引：375
作者：
Clausen, Tim [1 ]
Kaiser, Markus [2 ]
Huber, Robert [2 ,3 ,4 ]
Ehrmann, Michael [2 ,4 ]
机构：
[1] Res Inst Mol Pathol IMP, A-1030 Vienna, Austria
[2] Univ Duisburg Essen, Ctr Med Biotechnol, Fac Biol, D-45117 Essen, Germany
[3] Max Planck Inst Biochem, D-82152 Martinsried, Germany
[4] Cardiff Univ, Sch Biosci, Cardiff CF10 3US, S Glam, Wales
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2011年 / 12卷 / 03期
关键词：
HIGH-TEMPERATURE REQUIREMENT; AMYLOID PRECURSOR PROTEIN; IGF-BINDING PROTEINS; ENVELOPE-STRESS-RESPONSE; GROWTH-FACTOR IGF; SERINE-PROTEASE; ESCHERICHIA-COLI; PHOTOSYSTEM-II; PDZ DOMAIN; CRYSTAL-STRUCTURE;
D O I：
10.1038/nrm3065
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Controlled proteolysis underlies a vast diversity of protective and regulatory processes that are of key importance to cell fate. The unique molecular architecture of the widely conserved high temperature requirement A (HTRA) proteases has evolved to mediate critical aspects of ATP-independent protein quality control. The simple combination of a classic Ser protease domain and a carboxy-terminal peptide-binding domain produces cellular factors of remarkable structural and functional plasticity that allow cells to rapidly respond to the presence of misfolded or mislocalized polypeptides.
引用
收藏
页码：152 / 162
页数：11
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