Canine demodicosis: Hematological and biochemical alterations

被引:9
|
作者
Salem, N. Y. [1 ]
Abdel-Saeed, H. [1 ]
Farag, H. S. [2 ]
Ghandour, R. A. [3 ]
机构
[1] Cairo Univ, Fac Vet Med, Dept Internal Med & Infect Dis Internal Med, Giza, Egypt
[2] Cairo Univ, Fac Vet Med, Dept Internal Med & Infect Dis Infect Dis, Giza, Egypt
[3] Cairo Univ, Fac Vet Med, Dept Physiol, Giza, Egypt
关键词
antioxidant enzymes; canine generalized demodicosis; C-reactive protein; malondialdehyde; total antioxidant capacity; DOGS;
D O I
10.14202/vetworld.2020.68-72
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
Background and Aim: One of the most common cutaneous infections seen in veterinary canine practice is canine demodicosis. Demodicosis is a parasitic skin infection with a possible impact on acute-phase proteins (APPs) and oxidant-antioxidant balance. This study aimed to estimate the possible alterations in hematological, biochemical, oxidant-antioxidant, and APP (C-reactive protein [CRP] and albumin) profiles in naturally infected dogs with demodicosis. Materials and Methods: This study enrolled 21 dogs that were divided into two groups: The control group including 7 apparently healthy dogs and the diseased group including 14 dogs with generalized demodicosis. Demodicosis was confirmed through microscopic detection. Blood samples were collected for the estimation of CBC, total protein, albumin, alanine transaminase, aspartate aminotransferase, blood urea nitrogen, creatinine, superoxide dismutase (SOD), glutathione peroxidase (GPx), total antioxidant capacity (TAC), catalase (CAT), malondialdehyde (MDA), and CRP levels. Results: Significant reduction in red blood cells along with significant elevation in white blood cells was recorded in the diseased group compared with the control group. There was also significant elevation in MDA, TAC, SOD, and CRP levels along with significant reduction in GSH-Px and CAT levels in the diseased group. Conclusion: Based on these findings, a relationship between canine generalized demodicosis and oxidant-antioxidant disequilibrium could be suggested. Evidence of this relation manifested in the elevation in MDA and SOD levels and reduction in GPx and CAT levels as a consequence to the release of ROS resulting from Demodex infection. CRP elevation is expected in canine demodicosis.
引用
收藏
页码:68 / 72
页数:5
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