Proteomic analysis for neuronal vacuolation induced by MK-801 in rat retrosplenial cortex

被引：5
作者：
Shiotani, Motohiro [1 ]
Nakano, Kyoko [1 ]
Yamauchi, Emiko [2 ]
Oda, Yoshiya [2 ]
Hosokawa, Satoru [1 ]
Aoki, Toyohiko [1 ]
机构：
[1] Eisai Prod Creat Syst, Drug Safety Japan, Global Drug Safety, Biopharmaceut Assessments Core Funct Unit, Tsukuba, Ibaraki 3002635, Japan
[2] Eisai Prod Creat Syst, Biomarkers & Personalized Med Core Funct Unit, Andover, MA 01810 USA
来源：
JOURNAL OF TOXICOLOGICAL SCIENCES | 2011年 / 36卷 / 01期
关键词：
MK-801; NMDA; Vacuolation; Rat; Proteomics; PHENCYCLIDINE; NEUROTOXICITY; DIZOCILPINE; RECEPTORS; NECROSIS; PROTEIN; DRUGS;
D O I：
10.2131/jts.36.131
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Proteomic analysis was carried out for neuronal vacuolation in rat retrosplenial cortex (RSC) induced by MK-801, a N-methyl-D-aspartate (NMDA) receptor antagonist. Female rats were given a single subcutaneous (se) injection of either MK-801 (9 mg/kg in saline) or saline. Comparison of changes in proteins in the RSC region between MK-801- and saline-treated groups revealed that MK-801 induced changes in six proteins involved in vesicular transport (vesicle-fusing ATPase) and glycolysis (fructose-bisphosphate aldolase C, triosephosphate isomerase, and glyceraldehyde-3-phosphate dehydrogenase).
引用
收藏
页码：131 / 133
页数：3
相关论文
共 15 条
  • [1] AUER RN, 1994, ACTA NEUROPATHOL, V87, P1
  • [2] Sustained metabolic inhibition induces an increase in the content and phosphorylation of the NR2B subunit of N-methyl-D-aspartate receptors and a decrease in glutamate transport in the rat hippocampus in vivo
    Camacho, A.
    Montiel, T.
    Massieu, L.
    [J]. NEUROSCIENCE, 2007, 145 (03) : 873 - 886
  • [3] Oral administration of dextromethorphan neuronal vacuolation in the rat does not produce brain
    Carliss, R. D.
    Radovsky, A.
    Chengelis, C. R.
    O'Neill, T. P.
    Shuey, D. L.
    [J]. NEUROTOXICOLOGY, 2007, 28 (04) : 813 - 818
  • [4] The effects of temperature and scopolamine on N-methyl-D-aspartate antagonist-induced neuronal necrosis in the rat
    Colbourne, F
    Rakic, D
    Auer, RN
    [J]. NEUROSCIENCE, 1999, 90 (01) : 87 - 94
  • [5] Receptor mechanisms and circuitry underlying NMDA antagonist neurotoxicity
    Farber, NB
    Kim, SH
    Dikranian, K
    Jiang, XP
    Heinkel, C
    [J]. MOLECULAR PSYCHIATRY, 2002, 7 (01) : 32 - 43
  • [6] QUANTITATIVE-ANALYSIS OF FACTORS INFLUENCING NEURONAL NECROSIS INDUCED BY MK-801 IN THE RAT POSTERIOR CINGULATE RETROSPLENIAL CORTEX
    FIX, AS
    WOZNIAK, DF
    TRUEX, LL
    MCEWEN, M
    MILLER, JP
    OLNEY, JW
    [J]. BRAIN RESEARCH, 1995, 696 (1-2) : 194 - 204
  • [7] Effects of antipsychotic drugs on neurotoxicity, expression of fos-like protein and c-fos mRNA in the retrosplenial cortex after administration of dizocilpine
    Fujimura, M
    Hashimoto, K
    Yamagami, K
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2000, 398 (01) : 1 - 10
  • [8] Exponentially modified protein abundance index (emPAI) for estimation of absolute protein amount in proteomics by the number of sequenced peptides per protein
    Ishihama, Y
    Oda, Y
    Tabata, T
    Sato, T
    Nagasu, T
    Rappsilber, J
    Mann, M
    [J]. MOLECULAR & CELLULAR PROTEOMICS, 2005, 4 (09) : 1265 - 1272
  • [9] JAVITT DC, 1991, AM J PSYCHIAT, V148, P1301
  • [10] Excessive cerebrocortical release of acetylcholine induced by NMDA antagonists is reduced by GABAergic and α2-adrenergic agonists
    Kim, SH
    Price, MT
    Olney, JW
    Farber, NB
    [J]. MOLECULAR PSYCHIATRY, 1999, 4 (04) : 344 - 352
12