Aging and superoxide dismutase activity in cerebrospinal fluid

被引：22

作者：

Okabe, T ^{[1
]}

Hamaguchi, K ^{[1
]}

Inafuku, T ^{[1
]}

Hara, M ^{[1
]}

机构：

[1] SAITAMA MED SCH,DEPT NEUROL,MOROYAMA,SAITAMA 35004,JAPAN

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1996年 / 141卷 / 1-2期

关键词：

aging; oxidative stress; superoxide dismutase; central nervous system; cerebrospinal fluid; nitrite method;

D O I：

10.1016/0022-510X(96)00160-8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We investigated superoxide dismutase (SOD) activity in human cerebrospinal fluid (CSF) as an index of the aging process in the central nervous system (CNS). The subjects were 61 individuals aged 21-77 years, comprising 24 men and 37 women without organic disorders of the nervous system. SOD activity in CSF was measured by the nitrite method modified by Oyanagui, The results showed that SOD activity in CSF gradually increased with age and that the values of SOD activity after the fifth decade were significantly higher than those in the third and fourth decades. It might suggest that the productivity of SOD in the CNS gradually increased with age due to stimulation of various types of oxidative stress which accumulated in vivo especially after the fifth decade.

引用

页码：100 / 104

页数：5